teroxirone (Tepic)

08/01/2018 - "A synthetic triepoxide derivative, teroxirone, was reported effective against the growth of human lung cancer cells by injuring cellular mitochondria functions. "
03/01/2018 - "The small molecular weight triepoxide derivative, 1,3,5-triazine-2,4,6(1H,3H,5H)-tri-one-1,3,5-tri-(oxiranylmethyl) (teroxirone), has been proved effective against the proliferation of lung cancer cells. "
09/01/2017 - "In order to further understand the underlying mechanisms of lung cancer, the present study explored the targets of teroxirone. "
08/01/2018 - "The results consolidate the notion that teroxirone is a viable and effective therapeutic agent for eradicating human lung cancer."
08/01/2018 - "Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells."

01/01/2001 - "Several cases of contact allergy to TGIC have been reported during the last 10 years. "
05/01/1997 - "This case report emphasizes the importance of protecting both the skin and respiratory tract of workers against chemicals such as TGIC, capable of causing skin and respiratory allergy."
01/01/2001 - "Contact allergy to TGIC has developed in a factory producing the chemical, in a factory producing powder paints containing TGIC, and in industries using powder coating. "
06/01/1997 - "Patch testing showed a positive allergic reaction to only 5% triglycidyl isocyanurate in methyl ethyl ketone. "
07/01/2016 - "Two product types are of particular importance in contact allergy to polyester resin: powder paints cured by heat with TGIC as the cross-linker, and car putties. "

05/01/1986 - "Triglycidylurazol is a teroxirone derivative proposed for clinical trials on the basis of a broad spectrum of activity against murine tumors and a reduced potential for toxic manifestations at the injection site as compared to the parent compound. "
11/15/2013 - "The in vivo experiments demonstrated that teroxirone suppressed growth of xenograft tumors in nude mice. "
03/01/1984 - "As a follow-up to our initial results on the antineoplastic activity of alpha-1,3,5-triglycidyl-s-triazinetrione (alpha TGT, NSC-296934, Teroxirone), many new epoxyde derivatives were tested against murine tumours, mostly against P388 leukaemia, to determine their antineoplastic role and to characterize their specific effect against tumour cells in vivo, as well as to select an analogue with higher anti-cancer properties and superior pharmacological properties. "
01/01/1980 - "To extend initial results on the antineoplastic activity of alpha-1,3,5-triglycidyl-s-triazinetrione (TGT, NSC 296934), a novel triepoxidic derivative, this compound was tested in a series of murine transplantable tumors. "

10/01/1948 - "Study of a typhoid fever epidemic in Tepic Nayarit; during the spring of 1948."

06/01/2011 - "Occupational asthma caused by triglycidyl isocyanurate."
01/01/2011 - "Heated TGIC can cause occupational asthma from bystander exposure."
01/01/2011 - "Occupational asthma caused by heated triglycidyl isocyanurate."
05/01/1997 - "To our knowledge this is the first diagnosed case of occupational asthma caused by TGIC. "
06/01/2011 - "The aforementioned results demonstrate that TGIC inhalation induced immunologic occupational asthma, although no IgE mechanism was evidenced."