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guanoxabenz
Also Known As:
1-(2,6-dichlorobenzylideneamino)-3-hydroxyguanidine; guanoxabenz hydrochloride; guanoxabenz monohydrochloride
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amidines: 14
Guanidines: 29
Guanabenz: 131
guanoxabenz: 5
Related Diseases
1.
Mydriasis
03/01/1983 - "
4 Several antagonists of varying selectivities towards alpha 1- and alpha 2-adrenoceptors were tested for their ability to reverse the maximal mydriasis induced by guanoxabenz (0.3 mg/kg, i.v.).
"
09/01/1983 - "
Similarly, antagonist potency in the vas deferens was highly correlated with antagonist activity in reversing the centrally-mediated mydriasis induced by the selective alpha 2-adrenoceptor agonist, guanoxabenz, in pentobarbitone-anaesthetized rats.
"
03/01/1983 - "
6 Intracerebroventricular administration of RX 781094 (1.25-15 micrograms total dose) caused a rapid dose-related reversal of the maximal mydriasis induced by guanoxabenz (0.3 mg/kg, i.v.).
"
03/01/1983 - "
5 Topical application of RX 781094 (0.1 to 3% w/v solutions) onto one eye produced a slow reversal of guanoxabenz-induced mydriasis; the time course and degree of reversal were virtually the same in both eyes.
"
11/01/1984 - "
Compared with yohimbine, these analogues were, respectively, 36 and 18 times more potent intravenously and 5 and 7.5 times more potent orally in their antagonism of guanoxabenz-induced mydriasis in the pentobarbitone-anaesthetized rat.
"
2.
Pulmonary Edema
01/01/1983 - "
[Treatment of acute pulmonary edema with injectable guanoxabenz.
"
3.
AIDS-Related Complex (ARC)
11/01/1991 - "
2. Binding constants for 14 compounds for the three rat kidney alpha 2-adrenoceptor subtypes were determined by the simultaneous computer modelling of plain and ARC 239- and guanoxabenz-masked drug competition curves, plain ARC 239 and guanoxabenz competition curves as well as ARC 239-masked guanoxabenz competition curves.
"
11/01/1991 - "
1. Simultaneous computer modelling of plain and ARC 239- and guanoxabenz-masked [3H]-RX821002 saturation curves, plain ARC 239 and guanoxabenz competition curves as well as ARC 239-masked guanoxabenz competition curves revealed that the drugs bound to three alpha 2-adrenoceptor subtypes in the rat kidney with grossly differing selectivities.
"
Related Drugs and Biologics
1.
Yohimbine (Yocon)
2.
Pentobarbital (Nembutal)
3.
Idazoxan
4.
Prazosin (Minipress)
5.
2-methoxyidazoxan
6.
AR-C239
Related Therapies and Procedures
1.
Injections