clivorine

isolated from Ligularia dentata; structure in first source

Also Known As:

2,9-Dioxa-14-azabicyclo(9.5.1)heptadeca-4,11-diene-3,8,17-trione, 7-(acetyloxy)-4-ethenyl-6,7,14-trimethyl-, (1R,4Z,6S,7S)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Pyrrolizidine Alkaloids: 290
    - clivorine: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pyrrolizidine Alkaloids: 290
      - clivorine: 4

Experts

1.	Chou, Ming W: 2 articles (05/2008 - 05/2004)
2.	Fu, Peter P: 2 articles (05/2008 - 05/2004)
3.	Xia, Qingsu: 2 articles (05/2008 - 05/2004)
4.	Challa, Siva Reddy: 1 article (01/2020)
5.	Kodali, Tanvija: 1 article (01/2020)
6.	Koppula, Sirisha: 1 article (01/2020)
7.	Pawar, A Krishnamanjari: 1 article (01/2020)
8.	Pingili, Ravindra Babu: 1 article (01/2020)
9.	Toleti, Vyshnavi: 1 article (01/2020)
10.	Chen, Hui: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2004 - "These results also provide evidence that the principal metabolic activation pathway of clivorine leading to liver genotoxicity and tumorigenicity is (i) formation of the corresponding dehydropyrrolizidine (pyrrolic) derivative through oxidative N-demethylation of the necine base followed by ring closure and dehydration and (ii) binding of the pyrrolic metabolite to DNA leading to the DNA adduct formation and tumor initiation." 05/05/2008 - "Our mechanistic studies have determined that metabolism of the retronecine-type (riddelliine, retrorsine, and monocrotaline), heliotridine-type (lasiocarpine), and otonecine-type (clivorine) tumorigenic pyrrolizidine alkaloids in vivo and/or in vitro all generates a common set of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts responsible for tumor induction. "
2.	Ischemia 01/01/2020 - "Quercetin exhibited hepatoprotective activity against 2-butoxyethanol, acrylamide, acrylonitrile, aflatoxin B1, aroclor-1254, arsenic, sodium arsenite, azathioprine, cadmium chloride, carbon tetrachloride, chlorpyrifos, cyclosporine A, diazinon, dimethylnitrosamine, doxorubicin, epirubicin, ethanol, fenvalerate, isoniazide, rifampicin, lead acetate, lindane, D-galactosamine, methotrexate, methylmercury, nickel sulfate, paracetamol, perfluorooctanoic acid, polychlorinated biphenyls, pyrrolizidine alkaloid clivorine, rotenone, sodium fluoride, streptazotocin, tert-butyl hydroperoxide, thioacetamide, titanium dioxide, tumor necrosis factor-α, tripterygium glycoside, triptolide, ultraviolet A light, concavalin A, bisphenol, and ischemia-induced hepatotoxicity in various animal models due to its antioxidant, free radical-scavenging,anti-inflammatory, antiapoptotic, and cytochrome P450 2E1 (CYP2E1) inhibitory activities. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2017 - "Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication."
4.	Dehydration (Water Stress) 05/01/2004 - "These results also provide evidence that the principal metabolic activation pathway of clivorine leading to liver genotoxicity and tumorigenicity is (i) formation of the corresponding dehydropyrrolizidine (pyrrolic) derivative through oxidative N-demethylation of the necine base followed by ring closure and dehydration and (ii) binding of the pyrrolic metabolite to DNA leading to the DNA adduct formation and tumor initiation."

Related Drugs and Biologics

1.	Pyrrolizidine Alkaloids
2.	DNA Adducts
3.	Monocrotaline
4.	otonecine
5.	retronecine
6.	riddelliine
7.	dehydroretronecine
8.	lasiocarpine
9.	retrorsine (usaramine)
10.	tert-Butylhydroperoxide