|1.||Decaudin, Didier: 3 articles (11/2008 - 03/2002)|
|2.||Garcia-Segura, Luis M: 2 articles (05/2013 - 04/2005)|
|3.||Gavish, Moshe: 2 articles (11/2011 - 12/2008)|
|4.||Soustiel, Jean F: 2 articles (11/2011 - 12/2008)|
|5.||Vlodavsky, Eugene: 2 articles (11/2011 - 12/2008)|
|6.||Zaaroor, Menashe: 2 articles (11/2011 - 12/2008)|
|7.||Bribes, Estelle: 2 articles (09/2003 - 09/2002)|
|8.||Bourrie, Bernard: 2 articles (09/2003 - 09/2002)|
|9.||Casellas, Pierre: 2 articles (09/2003 - 09/2002)|
|10.||Liu, Xiaoming: 1 article (01/2016)|
|1.||Diabetic Neuropathies (Diabetic Neuropathy)
10/01/2004 - "In behavioral pharmacological experiments, EL mice were highly susceptible to convulsions induced by Ro 5-4864 (i.p.) in comparison with nonepileptic DDY mice. "
07/01/1991 - "The similarity in the effects of Ro 5-4864 and PTX suggests that antiGABAergic effects, perhaps along feedforward inhibitory pathways, are involved in both the seizures and enhanced E-S coupling."
07/01/1991 - "Both Ro 5-4864 and PTX produced a maximal increase in amplitude and decrease in threshold of the population spike (PS) evoked in the dentate gyrus (DG) by stimulation of the dorsal perforant path prior to peak seizure activity; start latency of the PS and initial slope and amplitude of the population slow wave (SW) were not changed. "
03/30/1987 - "The lack of coincidence between the developmental onset of susceptibility to Ro5-4864-induced seizures and the onset of supersensitivity to Ro5-4864-induced tonic seizures during the period of peak audiogenic seizure susceptibility in DBA/2 mice implies that more than one neurochemical mechanism is involved in the ability of Ro5-4864 to induce seizures in this strain. "
03/30/1987 - "Ontogeny of susceptibility to the convulsant, Ro 5-4864, and its relationship to audiogenic seizure susceptibility in inbred mice."
05/01/1992 - "These data indicate that the low affinity of Ro5-4864 for PBBS in human glioma cells compared to those in rat is due to interspecies receptor variation rather than impaired drug transport into human cells."
05/23/1997 - "On the basis of receptor-binding displacement assays in rat brain and glioma cells, 9 had appreciable binding affinity and displaced a prototypical PBR ligand, Ro 5-4864, with IC50 values between 289 and 390 nM. 9 displayed differential cytotoxicity to a variety of rat and human brain tumor cell lines. "
12/01/1989 - "In vitro studies of surgically removed specimens of human glioma demonstrated little binding of Ro5-4864 but high levels of binding of another selective ligand, PK 11195. "
06/01/1992 - "Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam."
12/01/1989 - "Although gliomas have a high density of the peripheral-type benzodiazepine binding site, PET scans with a selective ligand for this site, [11C] Ro5-4864, failed to demonstrate higher radioactivity levels in human gliomas than in brain. "
02/01/2007 - "Treatment of 10(-6) M 4'-chlorodiazepam and PK 11195 ligands of the PBR for 6 days enhanced the generation of LPO of the human neuroblastoma cells. "
03/01/2005 - "In the present study, we have shown that micromolar concentrations of FGIN-1-27 and Ro 5-4864, two chemically unrelated PBR ligands are toxic for both PBR-expressing SK-N-BE neuroblastoma cells and PBR-deficient Jurkat lymphoma cells. "
11/01/1984 - "We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells. "
09/01/1989 - "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture. "
|5.||Nervous System Diseases (Neurological Disorders)
04/01/1998 - "In fluorometric studies using NG108-15 cells, Ro 5-4864 depolarized mitochondrial membranes and, possibly as a consequence of this, raised intracellular Ca2+. Finally, we propose that MBR could be a major target of therapy for various neurological disorders, so drugs such as "mitochondrial membrane stabilizers" should be developed."
01/23/2013 - "Interestingly, TSPO expression returned to control levels or decreased substantially, when neuropathic pain healed naturally or was reversed by Ro5-4864, suggesting that the role of TSPO upregulation might be to promote recovery from the neurological disorder. "
|1.||PK 11195 (PK11195)
|3.||GABA-A Receptors (GABA(A) Receptor)
|8.||N,N- di- n- hexyl- 2- (4- fluorophenyl)indole- 3- acetamide
|9.||Neurotransmitter Agents (Neurotransmitter)
|3.||Intensive Care (Surgical Intensive Care)