|1.||Qian, W: 2 articles (08/2001 - 12/2000)|
|2.||Shichi, H: 2 articles (08/2001 - 12/2000)|
|3.||Renner, B: 1 article (08/2015)|
|4.||Brune, K: 1 article (08/2015)|
|5.||Tiegs, G: 1 article (08/2015)|
|6.||Mund, Menen E: 1 article (01/2015)|
|7.||Kumagai, Yoshito: 1 article (01/2015)|
|8.||Kamata, Shotaro: 1 article (01/2015)|
|9.||Abiko, Yumi: 1 article (01/2015)|
|10.||Hagiya, Yoshifumi: 1 article (01/2015)|
02/01/2001 - "STP (200 mg/kg) inhibited NAPQI synthesis through CYP inhibition, thus preventing both liver necrosis and mortality in rats."
08/01/1998 - "The primary cause of hepatic necrosis is rapid accumulation of NAPQI."
05/10/2013 - "It is well known that the NAPQI is a major intermediate of APAP, which causes necrosis of hepatocytes in rodents and humans. "
01/01/2011 - "The exact mechanism of acute liver failure secondary to acetaminophen toxicity is unknown, although a presumed mechanism of hepatocellular necrosis involving the accumulation of a toxic metabolite (N-acetyl-p-benzoquinoneimine) has been postulated. "
11/01/1999 - "Acetaminophen toxicity in hepatocytes is attributed to generation of the toxic metabolite N-acetyl-p-benzoquinoneimine, leading to depletion of intracellular glutathione, alteration of redox potential and ultimately, cellular necrosis. "
12/01/2000 - "These results suggest the following sequence of events as a possible mechanism of NAPQI-induced cataract. "
12/01/1999 - "Thus, when NAPQI was injected, P450 inducibility was not essential for cataract formation. "
12/01/1999 - "NAPQI produced cataract within a few hours (mean = 4 hr) both in B6 and D2 mice. "
08/01/2001 - "N-acetyl-p-benzoquinone imine (NAPQI), a semiquinone metabolite of acetaminophen, produces cataract in mice. "
12/01/2000 - "Co-injection of calpain inhibitors (N-Ac-Leu-Leu-norleucinol and N-Ac-Leu-Leu-methioninal) with NAPQI protected animals completely from cataract development, although a rise in free intracellular Ca(2+)in the lens epithelium was still observed. "
|4.||Chronic Obstructive Pulmonary Disease (COPD)
|4.||Glutathione (Reduced Glutathione)
|5.||DNA (Deoxyribonucleic Acid)
|6.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|7.||Reactive Oxygen Species (Oxygen Radicals)
|9.||Calcitonin Gene-Related Peptide