|1.||Wong, Diana M: 1 article (01/2008)|
|2.||Daniel, F Bernard: 1 article (01/2008)|
|3.||George, Michael H: 1 article (01/2008)|
|4.||DeAngelo, Anthony B: 1 article (01/2008)|
|5.||Soames, Anthony R: 1 article (04/2002)|
|6.||Kimber, Ian: 1 article (04/2002)|
|7.||Hasmall, Susan: 1 article (04/2002)|
|8.||Odum, Jenny: 1 article (04/2002)|
|9.||Elcombe, Clifford R: 1 article (04/2002)|
|10.||Stone, Susan: 1 article (04/2002)|
12/01/2000 - "Treating rats (DNS-X in the diet at 0.3% w/w) for 6 d leads to a hepatomegaly and a marked increase in liver peroxisomal palmitoyl-CoA oxidase activity. "
12/17/1990 - "In the livers a hepatomegaly, an induction of cytochrome P-450 IVA1 and induction of the activity of palmitoyl-CoA oxidase and carnitine acetyl-CoA transferase was found to be 180%, 1080%, 1300% and 1700% of control values, respectively. "
06/01/1987 - "At hypolipidemic doses the compound causes no hepatomegaly, no induction of peroxisomal catalase and palmitoyl-CoA oxidase activities, no smooth endoplasmic reticulum proliferation and no induction of microsomal cytochrome P-450 and of cytochrome P-450 dependent enzyme activities: aminopyrine (aminophenazone) N-demethylase, aniline hydroxylase, zoxazolamine hydroxylase and hexobarbital oxidase. "
|2.||Body Weight (Weight, Body)
01/01/1991 - "Treatment of rats with 1.0% dioxane in the drinking water for 5 days yielded no increase in liver/body weight nor induction of palmitoyl CoA oxidase, indicating that dioxane does not fit into the class of peroxisomal proliferating carcinogens. "
05/01/1987 - "Dose-related increases in organ (liver and kidney) weight/body weight ratios, individual cell necrosis in the liver, and hepatic microsomal NADPH cytochrome c reductase and peroxisomal palmitoyl-CoA oxidase and catalase activities were found in both the dosed-fed and gavage groups. "
12/01/1987 - "Five daily oral doses of di(2-ethylhexyl) phthalate (DEHP) (2 g/kg) given to rats on Days 2-6, 6-10, or 14-18 of lactation caused significant decreases in body weight and increases in hepatic peroxisomal enzymes palmitoyl CoA oxidase and carnitine acetyltransferase in the dams and their suckling pups. "
|5.||Liver Neoplasms (Liver Cancer)
06/15/1989 - "To evaluate the possibility that the promotional activity of WY-14,643 was more effective at a later stage in hepatocarcinogenesis, rats receiving a dose of DEN and then phenobarbital in the diet for 11 wk were changed to a diet containing WY-14,643 for an additional 11 or 43 wk. However, WY-14,643 feeding from wk 11 to 22 caused a reduction in volume density of ATPase-deficient foci relative to the volume density of foci at 11 wk. In addition, feeding WY-14,643 from wk 11 to 54 caused similar yields of hepatic neoplasms whether or not phenobarbital was fed for the initial 11 wk. WY-14,643 induced hepatic peroxisome proliferation as indicated by palmitoyl CoA oxidase activity regardless of prior treatment with DEN and/or phenobarbital. "
|2.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|8.||Thyrotropin (Thyroid-Stimulating Hormone)
|10.||NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)