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transcobalamin receptor

Also Known As:

CD320 antigen, mouse; transcobalamin receptors

Networked: 14 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - transcobalamin receptor: 14

Experts

1.	Quadros, Edward V: 4 articles (01/2019 - 06/2013)
2.	Sequeira, Jeffrey M: 4 articles (01/2019 - 06/2013)
3.	Abuyaman, Omar: 3 articles (09/2017 - 10/2015)
4.	Nexo, Ebba: 3 articles (09/2017 - 10/2015)
5.	Alarcon, Juan M: 2 articles (01/2019 - 01/2017)
6.	Arora, Kaveri: 2 articles (01/2019 - 01/2017)
7.	Bottiglieri, Teodoro: 2 articles (01/2019 - 06/2013)
8.	Nakayama, Yasumi: 2 articles (07/2013 - 06/2013)
9.	Gendron, Liberty N: 1 article (06/2020)
10.	Gunn, Jason R: 1 article (06/2020)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2020 - "Alkylcobalamins are actively transported into cells by transcobalamin receptors (TCblR), which are overexpressed in a variety of cancer types. " 07/22/2013 - "Saporin Conjugated Monoclonal Antibody to the Transcobalamin Receptor TCblR/CD320 Is Effective in Targeting and Destroying Cancer Cells." 11/21/2023 - "We have previously demonstrated that attaching drugs to the cobalamin scaffold provides selectivity for tumors over benign cells due to a high vitamin demand in these rapidly growing cells and an overexpression of transcobalamin receptors in a variety of cancer types. " 03/22/2001 - "Fluorescein, naphthofluorescein, and Oregon Green derivatives have been prepared in good yield by reaction of the fluorophore NHS-ester with beta-(3-aminopropyl)cobalamin to form fluorescent cobalamin conjugates (CobalaFluors) that are potentially suitable for the in vitro and in vivo imaging of transcobalamin receptors on cancer cells."
2.	Umbilical Hernia (Omphalocele) 05/01/2012 - "In the total study population, variants in the transcobalamin receptor gene (TCblR), rs2232775 (p.Q8R), and the MTHFR gene, rs1801131 (c.1298A>C), were significantly associated with omphalocele. " 05/01/2012 - "The finding that transcobalamin receptor (TCblR) and transporter (TCN2) SNPs and a BHMT SNP were associated with omphalocele suggests that disruption of methylation reactions, in which folate, vitamin B12, and homocysteine play critical parts, may be a risk factor for omphalocele. "
3.	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 01/01/2017 - "Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse." 06/01/2013 - "The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system."
4.	Dementia (Dementias) 09/01/2017 - "The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates with the dementia-related biomarkers phospho-tau and total-tau. " 10/01/2015 - "The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta."
5.	Hyperhomocysteinemia 08/01/2012 - "A previously healthy 7-week-old boy developed bilateral central retinal artery occlusions in the presence of hyperhomocysteinemia and elevated serum methylmalonic acid and was found to have a transcobalamin receptor mutation. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	Saporins
3.	Vitamin B 12 (Cyanocobalamin)
4.	Biomarkers (Surrogate Marker)
5.	Transcobalamins (Transcobalamin II)
6.	Proteome
7.	Fluorescein (Funduscein)
8.	tau Proteins (tau Protein)
9.	Amyloid beta-Peptides
10.	Vitamins