10-hydroxycamptothecin

02/01/2020 - "Nevertheless, co-treatment with tetrandine is known to reverse the resistance of multi-drug resistant cancers, and may present an effective strategy to improve the efficacy of 10-hydroxycamptothecin. "
05/01/2016 - "In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells."
12/01/2003 - "[Preliminary study of lyophilized 10-hydroxycamptothecin in advanced or recurrent malignancies]."
02/01/2020 - "However, the 10-hydroxycamptothecin cannot be widely applied in clinics due to fast elimination and resistance of various cancers to the drug. "
02/01/2020 - "10-Hydroxycamptothecin is a drug to cure various cancers. "

05/01/2009 - "[Efficacy of chemotherapy using 10-hydroxycamptothecin on recurrent or refractory neuroblastoma in children]."
01/01/2016 - "10-Hydroxycamptothecin induces apoptosis in human neuroblastoma SMS-KCNR cells through p53, cytochrome c and caspase 3 pathways."

08/01/2000 - "Differentiation of human hepatoma Hep G2 cells induced by 10-hydroxycamptothecin."
04/01/2000 - "Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells."
07/01/1999 - "Apoptosis induction and cell cycle perturbation in human hepatoma hep G2 cells by 10-hydroxycamptothecin."
12/01/1981 - "[Effects of 10-hydroxycamptothecin on cAMP and cGMP levels in hepatoma and liver tissue of mice (author's transl)]."
01/01/1979 - "[The influence of 10-hydroxycamptothecin on the ultrastructure of ascitic hepatoma cells in mice (author's transl)]."

05/01/2006 - "Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer."
01/01/2022 - "In this study, an active targeting system (HM NCs) was constructed by covalent cross-linking of mannose and anticancer drug 10-hydroxycamptothecin via redox-responsive disulfide bonds for enhanced colon cancer chemotherapy. "
05/01/1997 - "The present study explored the potential use of natural product topoisomerase I inhibitors, 10-hydroxycamptothecin (HCPT) and camptothecin (CPT), in the treatment of human colon cancers. "

01/01/1999 - "To study whether 10-hydroxycamptothecin (HPT) can induce apoptosis in bladder cancer cell and establish methods for detecting apoptotic cells. "
04/01/1998 - "To study the emechanisms of 10-Hydroxycamptothecine (HPT) inhibiting human urinary bladder cancer. "
01/01/1999 - "[Detection of apoptosis exposed to 10-hydroxycamptothecin in T24 human urinary bladder cancer cells]."
04/01/1998 - "The induction of apoptosis is a very important mechanism of 10-Hydroxycamptothecine to treat urinary bladder cancer cells."
06/01/2018 - "Here, a smart disulfide-crosslinked polypeptide nanogel of poly(l-lysine)-poly(l-phenylalanine-co-l-cystine) (PLL-P(LP-co-LC)) is developed to deliver 10-hydroxycamptothecin (HCPT) for treatment of orthotopic bladder cancer. "