protoporphyrin IX

07/01/2016 - "Moreover, upon endogenous generation and accumulation of PpIX in cancer cells, efficient photodynamic ablation of cancer cells after light irradiation is demonstrated with easy regulation for optimal therapeutic efficacy. "
01/01/2023 - "Overall, compared to wide-field imaging, confocal microscopy significantly improved diagnostic accuracy and was better at detecting low concentrations of PpIX and FNa, resulting in improved tumor delineation. "
01/01/2016 - "These results suggest the potential and usefulness of the background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions, and we expect this method to be beneficial for intraoperative and rapid cancer diagnosis."
02/15/1997 - "Tumor PpIX concentrations were significantly greater than in other tissues except liver. "
06/01/2011 - "Importantly, PpIX-GC-NPs-treated mice presented prolonged blood circulation, enhanced tumor targeting ability, and improved in vivo therapeutic efficiency in tumor-bearing mice, compared to that of free PpIX-treated mice. "

01/01/2019 - "A recent in-vitro study demonstrated that AEDs result in significant reduction of PpIX synthesis in glioma cells. "
01/01/2017 - "The value of PpIX-guided resection of malignant gliomas has been demonstrated in prospective randomized clinical studies in which a twofold greater extent of resection and improved progression-free survival have been observed. "
01/01/2020 - "Corrigendum: Quantitative Modulation of PpIX Fluorescence and Improved Glioma Visualization."
05/10/2019 - "The value of visible 5-ALA fluorescence and quantitative protoporphyrin IX analysis for improved surgery of suspected low-grade gliomas."
01/01/2019 - "Quantitative Modulation of PpIX Fluorescence and Improved Glioma Visualization."

04/01/2020 - "Corrigendum to "Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization"."
12/01/2019 - "Protoporphyrin IX tracer fluorescence modulation for improved brain tumor cell lines visualization."
01/01/2017 - "Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. "
01/01/2013 - "Clinical studies have revealed high selectivity of 5-ALA-induced protoporphyrin IX accumulation in different brain tumors. "
01/01/2022 - "First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence."

06/01/2000 - "Finally, these results show that the esterification of ALA can greatly increase its cellular uptake, so generating more intracellular PpIX, improved tumour cell photosensitization and enhanced photocytotoxicity."
01/01/2014 - "ALAS2 variants that cause high levels of PPIX accumulation provide a new means of targeted, and potentially enhanced, photosensitization. "
06/01/2007 - "These demonstrated an overall damage to the PSI and PSII reaction centers by (1)O(2) produced in response to photosensitization reaction of protoporphyrin IX in AF-Na-treated cucumber seedlings."
06/01/2007 - "Impairment of the photosynthetic apparatus by oxidative stress induced by photosensitization reaction of protoporphyrin IX."
07/01/2004 - "Increased PPIX accumulation in tumour and inflamed brain tissue in comparison to normal brain tissue suggest the feasibility of selective photosensitization of such tissue."

01/01/2010 - "Percentage change in fluorescence intensity integrated over 610-700 nm (attributed to PpIX) of posttreated compared to pretreated cells showed statistically significant differences between four breast cancer and two normal mammary epithelial cell lines. "
03/27/2012 - "In vitro study on the ROS formation enabled by PpIX-conjugated Au NPs in human breast cancer cells (MDA-MB-231) revealed the similar size-dependent enhancement of intracellular ROS formation, while the enhancement greatly depended on cellular uptake of Au NPs. "
09/01/2003 - "In subsequent studies, breast tumor COH-BR1 cells in serum-free medium were treated with 1 mM ALA for 15 min and then without ALA for 3.75 h, allowing biogenerated PpIX to diffuse to extramitochondrial sites, including plasma membrane. "
11/15/2002 - "An initial goal of this study was to ascertain how the PpIX-sensitized death mechanism for a breast tumor line (COH-BR1 cells) might be influenced by the conditions of ALA exposure in vitro. "
09/01/2020 - "Our results showed that 5-ALA exhibited a higher PpIX fluorescence in both breast cancer cells for 4 h incubation. "