diallyl disulfide (diallyl disulphide)

01/20/2022 - "Diallyl disulfide (DADS) is one of the main bioactive organosulfur compounds of garlic, and its potential against various cancer models has been demonstrated. "
11/01/1996 - "However, oil-soluble compounds such as diallyl disulfide are effective in reducing the proliferation of neoplasms. "
08/01/2017 - "In the present study, we have investigated the in vitro anticancer activity of Diallyl disulfide derivatives (5a-5l and 7e-7m) against human cancer cell lines. "
01/01/2001 - "The results of this study indicate that diallyl disulfide inhibits the growth of H-ras oncogene transformed tumors in vivo by inhibiting the membrane association of p21(H-ras) and that the allyl group may be an important determinant in the inhibitory effect of this organosulfide on tumor growth."
01/01/1998 - "The present studies reveal the antiproliferative property of diallyl disulfide (DADS) in cultured human colon tumor cells (HCT-15) relative to its ability to decrease the proportion of cells in the G1 phase and increase the proportion of cells in the G2/M phase. "

01/01/1997 - "Inhibitory potential for colon and renal carcinogenesis was observed in rats treated with diallyl disulfide. "
02/01/2006 - "Chemoprevention of rat prostate carcinogenesis by diallyl disulfide, an organosulfur compound of garlic."
05/01/2011 - "Diallyl disulfide (DADS), a sulfur compound derived from garlic, has been shown to have protective effects against colon carcinogenesis in several studies performed in rodent models. "
09/01/1992 - "Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats."
02/01/2006 - "So the present chemoprevention study was conducted to evaluate the activity of diallyl disulfide as an anticancer agent in prostate carcinogenesis of male Sprague-Dawley rats. "

01/01/2022 - "The current study aimed to investigate the roles of diallyl disulfide (DADS) in LPS-driven inflammation in vitro and in vivo. "
01/01/2018 - "This study aims to explore the effects of diallyl disulfide (DADS) on IL-1β-mediated inflammation and oxidative stress in human adipose derived mesenchymal stem cells (hADSCs) during chondrogenesis. "
06/01/2017 - "Diallyl Disulfide Suppresses the Inflammation and Apoptosis Resistance Induced by DCA Through ROS and the NF-κB Signaling Pathway in Human Barrett's Epithelial Cells."
02/01/2015 - "Effects of diallyl disulphide on small intestinal inflammation and intestinal microbiota were also assessed. "
04/01/2015 - "Furthermore, application of an H2S-releasing molecule, diallyl disulfide (DADS), stabilized colonic HIF-1α expression, up-regulated hypoxia-responsive genes, and reduced the severity of disease during peak inflammation. "

07/15/2004 - "We examined the effects of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, on human HepG2 hepatoma cells to better understand its effect on apoptosis and apoptosis-related genes. "
07/15/2004 - "Enhancement of diallyl disulfide-induced apoptosis by inhibitors of MAPKs in human HepG2 hepatoma cells."
01/01/2001 - "The present study shows that diallyl disulfide, found in garlic, is effective in inhibiting [3H]-thymidine incorporation in human hepatoma HepG2 cell cultures. "
11/24/2022 - "Here, we examined whether diallyl disulfide (DADS; 50-200 μM) and sorafenib (SORA; 8 μM), either alone or in combination, were toxic to hepatocellular carcinoma cells (HepG2) in vitro. "
11/24/2022 - "Diallyl Disulfide Induces Chemosensitization to Sorafenib, Autophagy, and Cell Cycle Arrest and Inhibits Invasion in Hepatocellular Carcinoma."

11/01/2019 - "Fatty liver and alteration of the gut microbiome induced by diallyl disulfide."
05/03/2023 - "Diallyl disulfide (DADS), a major active compound in garlic, has many health benefits for patients with metabolic diseases, especially cardiovascular or fatty liver diseases. "
08/01/2019 - "Diallyl disulfide attenuates non‑alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, lipid peroxidation and inflammation in mice."
11/07/2012 - "This study investigated the molecular mechanisms of garlic oil (GO) or diallyl disulfide (DADS) imparted hepatoprotection against alcohol induced fatty liver in C57BL/6 mice using microarray-based global gene expression analysis. "
06/01/2022 - "Diallyl disulfide ameliorates ethanol-induced liver steatosis and inflammation by maintaining the fatty acid catabolism and regulating the gut-liver axis."