bacillomycin D

from strain of Bacillus subtilis; contains lipid moiety which is mixture of 3-amino-12-methyltridecanoic acid (40%) & 3-amino-12-methyltetradecanoic acid (60%) & peptide moiety: L-Asp(1), L-Glu(1), L-Pro(1), D-Ser(1), L-Thr(1) & D-Tyr(1); two moieties joined by threonyl beta-aminoacid linkage; see also bacillomycin L & bacillomycin S

Also Known As:

Networked: 10 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lu, Zhaoxin: 3 articles (01/2019 - 03/2015)
2.	Lv, Fengxia: 2 articles (01/2019 - 03/2015)
3.	Sun, Jing: 2 articles (01/2019 - 05/2018)
4.	Bie, Xiaomei: 2 articles (05/2018 - 03/2015)
5.	Qian, Shiquan: 2 articles (05/2018 - 03/2015)
6.	Lin, F: 1 article (09/2021)
7.	Liu, Y: 1 article (09/2021)
8.	Lu, Y: 1 article (09/2021)
9.	Lu, Z: 1 article (09/2021)
10.	Sun, J: 1 article (09/2021)

Related Diseases

1.	Coma (Comas) 05/02/2018 - "Finally, it was found that the deletion of rapC gene in fmbJ significantly improved bacillomycin D production from 240.7 ± 18.9 to 360.8 ± 30.7 mg/L, attributed to the increased the expression of bacillomycin D synthesis-related genes through enhancing the transcriptional level of comA, comP, and phrC. " 03/01/2015 - "Also, inulin up-regulated ComA, DegU, SigmaH and Spo0A and therefore promoted the high production of bacillomycin D. " 09/01/2021 - "In the study, we investigated the regulatory effects of these genes (codY, comA, degU and spo0A) on the biosynthesis of three lipopeptides (bacillomycin D, fengycin and surfactin) in Bacillus amyloliquefaciens. " 03/01/2015 - "The effect of inulin on the production of bacillomycin D and the levels of mRNA of bacillomycin D synthetase genes: bmyA (BYA), bmyB (BYB), bmyC (BYC), the thioesterase gene (TE) and regulating genes: AbrB, ComA, DegU, PhrC, SigmaH and Spo0A in Bacillus subtilis fmbJ were investigated. "
2.	Neoplasms (Cancer) 02/25/2018 - "Component 1 and component 2 were detected as C-15 Bacillomycin D and C-16 Bacillomycin D by HPLC-MS and ESI-MS/MS. Secondly, the effect of C-15 Bacillomycin D, C-16 Bacillomycin D and their mixture (1:1, mol:mol) on cell proliferation was measured using human cancer cells (Hela, MG, Hep-G2 and HT-29). " 01/10/2018 - "All compounds 1-10 were assayed for their cytotoxicities against human cancer cell lines HepG2 and MCF7, and the bacillomycin D analogues 7-10 showed moderate cytotoxicities with IC50 values from 2.9 ± 0.1 to 8.2 ± 0.2 µM. " 09/01/2013 - "Induction of apoptosis in human cancer cells by a Bacillus lipopeptide bacillomycin D."
3.	Infections 07/01/2021 - "We provide an alternative treatment option to Staphylococcus infections by investigating the specific anti-staphylococcal activity of C15 -bacillomycin D produced by a B. " 06/10/2015 - "Interestingly, [Ile(7)]surfactins showed synergistic activities with bacillomycin D to gray mold disease on cucumber leaves but not to Botrytis cinerea itself in vitro, suggesting that the synergistic effects might be on infection processes of the fungus. " 02/01/2016 - "Application of the lipopeptide bacillomycin D and the antifungal drug amphotericin B in medical devices may offer a promising alternative for topical treatment of Candida-associated infections in the setting of a wound."
4.	Wounds and Injuries (Trauma) 02/01/2016 - "Application of the lipopeptide bacillomycin D and the antifungal drug amphotericin B in medical devices may offer a promising alternative for topical treatment of Candida-associated infections in the setting of a wound."
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "The bacillomycin D monomers containing longer fatty acid chains better induced apoptosis in Bgc-823, Sgc-7901, and Hgc-27 gastric cancer cells. "

Related Drugs and Biologics

1.	Lipopeptides
2.	fengycin
3.	Messenger RNA (mRNA)
4.	Ligases (Synthetase)
5.	Inulin
6.	Fatty Acids (Saturated Fatty Acids)
7.	Amphotericin B (Amphotericin)