calcium-hydrogen antiporters

provides mechanism to keep intracellular Ca concentration low; electroneutral; is heat-labile & insensitive to low concentrations of ruthenium red & lanthanides

Also Known As:

ATCAX2 protein, Arabidopsis; AtHCX1 protein, Arabidopsis; CAX1 protein, Arabidopsis; CAX1-like protein, Arabidopsis; CAX2 protein, Arabidopsis; Ca(2+)-H(+) antiport; Ca(2+)-H(+) antiporter; Ca(2+)-H(+) exchanger; H-Ca antiporter; calcium-proton antiporter

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        calcium-hydrogen antiporters: 5
        Cation Transport Proteins: 22
        calcium-hydrogen antiporters: 5
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Antiporters: 369
        calcium-hydrogen antiporters: 5
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        calcium-hydrogen antiporters: 5
        Cation Transport Proteins: 22
        calcium-hydrogen antiporters: 5

Experts

1.	Park, Sunghun: 2 articles (06/2011 - 01/2007)
2.	Clapham, David E: 1 article (06/2013)
3.	Clish, Clary B: 1 article (06/2013)
4.	Jiang, Dawei: 1 article (06/2013)
5.	Zhao, Linlin: 1 article (06/2013)
6.	Mitcham, Elizabeth J: 1 article (06/2011)
7.	Padda, Malkeet: 1 article (06/2011)
8.	Tonetto de Freitas, Sergio: 1 article (06/2011)
9.	Wu, Qingyu: 1 article (06/2011)
10.	Connolly, Erin L: 1 article (08/2008)

Related Diseases

1.	X-Linked 1 Spinocerebellar Ataxia 01/01/2007 - "Furthermore, transgenic plants expressing sCAX1 display increased Ca(2+) accumulation and heightened activity of vacuolar Ca(2+)/H(+) antiport. " 06/01/2011 - "The objectives of this work were to analyze the effects of high expression of the constitutively functional Arabidopsis (Arabidopsis thaliana) Ca(2+)/H(+) exchanger (sCAX1) tonoplast protein in tomato fruit on cellular Ca partitioning and distribution, membrane integrity, and the transcriptional profile of genes potentially involved in BER development. " 08/01/2008 - "Recent efforts to increase the levels of Ca in the edible portions of plants have used a modified calcium/proton antiporter [known as short cation exchanger 1 (sCAX1)] to increase Ca transport into vacuoles. " 01/01/2007 - "In yeast expression assays, a 36 amino acid N-terminal truncation of CAX1, termed sCAX1, and variants with specific mutations in this N-terminus, show CAX1-mediated Ca(2+)/H(+) antiport activity. "
2.	Wolf-Hirschhorn Syndrome 06/11/2013 - "Leucine zipper-EF-hand containing transmembrane protein 1 (Letm1), one of the genes deleted in Wolf-Hirschhorn syndrome, encodes a putative mitochondrial Ca(2+)/H(+) antiporter. "
3.	Acidosis 10/01/1999 - "However, NMDA/KCl-induced acidosis was largely prevented by glycolytic inhibitors (iodoacetate or deoxyglucose in glucose-free medium) or by inhibitors of the Ca(2+)-ATPase (i.e., Ca(2+)/H(+) exchanger), including La(3+), orthovanadate, eosin B, or an extracellular pH of 8.5. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	N-Methylaspartate (NMDA)
3.	Vanadates (Orthovanadate)
4.	Eosine I Bluish
5.	Glucose (Dextrose)
6.	Deoxyglucose (2 Deoxy D glucose)
7.	Cations
8.	Amino Acids
9.	Adenosine Triphosphatases (ATPase)