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4-hydroxy-2-nonenal (4-hydroxynonenal)

cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation
Also Known As:
4-hydroxynonenal; 4-HNE cpd; 4-hydroxy-2,3-nonenal; 4-hydroxy-2-nonenal, (E)-isomer; 4-hydroxynonen-2-al
Networked: 483 relevant articles (9 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Pizzimenti, Stefania: 12 articles (12/2015 - 09/2004)
2. Barrera, Giuseppina: 12 articles (12/2015 - 09/2004)
3. Toaldo, Cristina: 10 articles (12/2015 - 01/2005)
4. Petersen, Dennis R: 10 articles (03/2015 - 10/2005)
5. Zarkovic, Neven: 9 articles (04/2015 - 01/2005)
6. Waeg, Georg: 7 articles (04/2013 - 01/2007)
7. Cipak, Ana: 7 articles (02/2013 - 01/2005)
8. Pettazzoni, Piergiorgio: 6 articles (12/2015 - 01/2010)
9. Biasi, Fiorella: 6 articles (12/2015 - 01/2005)
10. Shearn, Colin T: 6 articles (03/2015 - 05/2011)

Related Diseases

1. Neoplasms (Cancer)
2. Ischemia
3. Neuroblastoma
4. Colorectal Neoplasms (Colorectal Cancer)
5. Adenocarcinoma
08/01/2003 - "In vivo studies on human colon adenocarcinoma showed decreased transforming growth factor-beta1 (TGF-beta1) antiproliferative cytokine content in tumour tissue related to malignancy progression, with a corresponding decrease in lipid peroxidation aldehydic end-product, 4-hydroxynonenal (HNE). "
01/01/2005 - "4-hydroxynonenal and TGF-beta1 concur in inducing antiproliferative effects on the CaCo-2 human colon adenocarcinoma cell line."
01/01/2006 - "The TRAMP (Transgenic Adenocarcinoma of the Mouse Prostate) mouse model was used to demonstrate the OS/NS-associated damage, as evident by 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE)-protein-adducts and nitrotyrosine (Ntyr), in prostatic premalignant lesions, and to evaluate the antioxidant efficacy of various dietary supplements [natural antioxidant (NAO) from spinach extracts, (-) epigallocatechin-3-gallate (EGCG), or N-acetylcystein (NAC)] during the early PCa development. "
08/01/2005 - "We further show that progression to prostate adenocarcinoma, as occurs in compound mutant mice lacking Nkx3.1 as well as the Pten tumor suppressor, is correlated with a further deregulation of antioxidants, including superoxide dismutase enzymes, and more profound accumulations of oxidative damage to DNA and protein, the latter manifested by increased levels of 4-hydroxynonenal. "
08/01/1999 - "Here we studied human colorectal adenocarcinomas and adenomas to determine whether oxidative stress is imposed on cancer cells in vivo and used specific antibodies against 8-hydroxy-2'-deoxyguanosine (8-OHdG), 4-hydroxy-2-nonenal (HNE)-modified proteins, and 3-nitro-L-tyrosine (3-NT) to determine whether there is an association between oxidative stress and cellular proliferation. "

Related Drugs and Biologics

1. Malondialdehyde (Propanedial)
2. 3-nitrotyrosine
3. 8-hydroxy-2'-deoxyguanosine
4. Hydrogen Peroxide (Hydroperoxide)
5. Carbon Monoxide
6. Advanced Glycosylation End Products
7. triphenyltetrazolium
8. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9. Lipoproteins (Lipoprotein)
10. Chemokine CCL2 (Monocyte Chemoattractant Protein 1)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Oral Administration
3. Continuous Ambulatory Peritoneal Dialysis (CAPD)
4. Artificial Respiration (Mechanical Ventilation)
5. Replantation