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butylbenzyl phthalate (benzyl butyl phthalate)

Also Known As:
benzyl butyl phthalate; butyl benzyl phthalate; BBPHT; 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester
Networked: 24 relevant articles (1 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Tsai, Eing-Mei: 6 articles (12/2015 - 01/2012)
2. Kuo, Po-Lin: 5 articles (12/2015 - 01/2012)
3. Tsai, Cheng-Fang: 5 articles (01/2014 - 01/2012)
4. Hsieh, Tsung-Hua: 4 articles (01/2014 - 01/2012)
5. Hsu, Chia-Yi: 4 articles (01/2014 - 01/2012)
6. Lee, Jau-Nan: 4 articles (01/2014 - 01/2012)
7. Miller, Rachel L: 3 articles (11/2015 - 10/2012)
8. Calafat, Antonia M: 3 articles (11/2015 - 10/2012)
9. Whyatt, Robin M: 3 articles (11/2015 - 10/2012)
10. Perzanowski, Matthew S: 3 articles (11/2015 - 10/2012)

Related Diseases

1. Neoplasms (Cancer)
11/01/1982 - "Butyl benzyl phthalate did not cause tumors in male or female mice, but the incidence of myelomonocytic leukemia in butyl benzyl phthalate-treated female rats was significantly greater than that in the controls. "
06/01/2007 - "In particular, the increased levels of cyclin D3, which in mammalian cells plays a critical role in G1 to S transition and is a putative proto-oncogene in benzyl butyl phthalate treated cells, suggested a possible effect of the endocrine disruptor in cancer processes."
08/01/2012 - "Here we tested the hypothesis that phthalates such as butyl benzyl phthalate and di-n-butyl phthalate induce EMT in R2d cells, a stem cell-derived human breast epithelial cell line that is responsive to estradiol for tumor development. "
02/01/2012 - "Here we show that treatments with the phthalates n-butyl benzyl phthalate (BBP) and dibutyl phthalate (DBP) at 1 μM induced proliferation (BBP, 3.2-fold; DBP, 3.2-fold), migration (BBP, 2.6-fold; DBP, 2.6-fold), invasion (BBP, 2.7-fold; DBP, 3.1-fold), and tumor formation (EC(50): BBP, 0.12 μM; DBP, 0.22 μM) in estrogen receptor (ER)-negative breast cancer cells (MDA-MB-231). "
01/01/2012 - "To elucidate the effect of the most widely used industrial phthalate, n-butyl benzyl phthalate (BBP), on cancer progression, we evaluated the results of BBP treatment using a whole human genome cDNA microarray and MetaCore software and selected candidate genes whose expression was changed by more than ten-fold by BBP compared with controls to analyze the signaling pathways in human breast cancer initiating cells (R2d). "
2. Leukemia
3. Asthma (Bronchial Asthma)
4. Breast Neoplasms (Breast Cancer)
5. Eczema

Related Drugs and Biologics

1. phthalic acid (phthalate)
2. Diethylhexyl Phthalate (DEHP)
3. 4-boronic acid benzophenone
4. Plasticizers
5. Dibutyl Phthalate (Butyl Phthalate)
6. di-n-octyl phthalate
7. 1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)
8. Estradiol (Estrace)
9. diisodecyl phthalate
10. dinoseb (DNBP)