renin inhibitory peptide

angiotensinogen analog

Also Known As:

Pro-His-Pro-Phe-His-Phe-Phe-Val-Tyr-Lys; prolyl-histidyl-prolyl-phenylalanyl-histidyl-phenylalanyl-phenylalanyl-valyl-tyrosyl-lysyl; L-Lysine, N(2)-(N-(N-(N-(N-(N-(N-(1-(N-L-prolyl-L-histidyl)-L-prolyl)-L-phenylalanyl)-L-histidyl)-L-phenylalanyl)-L-phenylalanyl)-L-valyl)-L-tyrosyl)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - renin inhibitory peptide: 2

Related Diseases

1.	Body Weight (Weight, Body) 09/01/1980 - "In five studies in sodium-depleted monkeys, an infusion of 2 mg of the peptide per kg of body weight resulted in a reduction of mean arterial pressure (MAP) from 105 +/- 4 to 79 +/- 3 mm Hg, which is not significantly different from the response to 1 mg of the angiotensin I-converting enzyme inhibitor teprotide per kg. In uninephrectomized monkeys, inflation of a suprarenal aortic cuff caused an increase in MAP from 107 +/- 3 to 131 +/- 3 mm Hg. Infusion of 0.6 mg of the renin-inhibitory peptide per kg was followed by a return of blood pressure to 107 +/- 4 mm Hg--a depressor response similar to that observed with teprotide. "
2.	Renovascular Hypertension (Goldblatt Syndrome) 02/01/1987 - "These data demonstrate that ACHPA-containing renin inhibitory peptide and enalaprilat are equally effective antihypertensive agents in dogs with renin-dependent renovascular hypertension and lend credence to the contention that the renin-angiotensin system supports renal function in hypertensive states in which renin levels are elevated."

Related Drugs and Biologics

1.	Teprotide
2.	Sodium
3.	Peptides (Polypeptides)
4.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
5.	Enalaprilat (Vasotec)
6.	Renin
7.	Antihypertensive Agents (Antihypertensives)