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1,2-epoxybutane
RN given refers to cpd with unspecified isomeric designation
Also Known As:
1,2-butylene oxide; 1,2-epoxybutane, (+-)-isomer; 1,2-epoxybutane, (R)-isomer; 1,2-epoxybutane, (S)-isomer; 1-butene oxide; oxirane, ethyl-
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ethers: 242
Cyclic Ethers: 12
Epoxy Compounds: 689
1,2-epoxybutane: 3
Related Diseases
1.
Carcinogenesis
03/01/1988 - "
Two-Year Studies: The 2-year toxicology and carcinogenesis studies of 1,2-epoxybutane were conducted by exposing groups of 50 animals per species and sex to the chemical by inhalation, 6 hours per day 5 days per week.
"
03/01/1988 - "
NTP Toxicology and Carcinogenesis Studies of 1,2-Epoxybutane (CAS No. 106-88-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
"
2.
Neoplasms (Cancer)
10/31/1997 - "
Nearly 500 long-term rodent carcinogenicity studies carried out by the National Cancer Institute and the National Toxicology Program were examined, and 12 chemicals were identified that produced nasal tumors: allyl glycidol ether, p-cresidine, 1,2-dibromo-3-chloropropane, 1,2-dibromoethane, 2,3-dibromo-1-propanol, dimethylvinyl chloride, 1,4-dioxane, 1,2-epoxybutane, iodinated glycerol, procarbazine, propylene oxide, and 2,6-xylidine.
"
3.
Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar)
03/01/1988 - "
Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined).
"
4.
Carcinoma (Carcinomatosis)
03/01/1988 - "
Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined).
"
5.
Adenoma (Adenomas)
03/01/1988 - "
Conclusions: Under the conditions of these 2-year inhalation studies, there was clear evidence of carcinogenic activity of 1,2-epoxybutane for male F344/N rats, as shown by an increased incidence of papillary adenomas of the nasal cavity, alveolar/bronchiolar carcinomas, and alveolar/bronchiolar adenomas and carcinomas (combined).
"
Related Drugs and Biologics
1.
Ethylene Dibromide (1,2 Dibromoethane)
2.
Procarbazine (Matulane)
3.
Ether (Diethyl Ether)
4.
Chlorides
5.
1,4-dioxane (dioxane)
6.
2,3-dibromopropanol
7.
iodinated glycerol
8.
cresidine
9.
propylene oxide
10.
2,6-xylidine