indirubin

01/01/2015 - "These investigations explored the use of indirubin in different types of cancer and reported the synthesis of novel derivatives with improved chemical and pharmacokinetic properties. "
09/01/2018 - "Collectively our studies indicate that perturbation of microtubule polymerization dynamics could be one of the possible mechanisms behind the anti-cancer activities of indirubin."
01/01/2018 - "The present study aimed to analyze the effects of indirubin on cell proliferation, migration, invasion, and angiogenesis of tumor-derived endothelial cells (Td-EC). "
02/08/2009 - "Our previous study demonstrated that the novel indirubin derivative, 5'-nitro-indirubinoxime (5'-NIO), effectively arrested the tumor growth through the inhibition of cell proliferation and the induction of apoptosis. "
12/05/2023 - "Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer."

02/01/2017 - "We explored the mechanism whereby indirubin exerts protective effects against LPS-induced inflammation of mouse mammary epithelial cells (MMECs). "
01/01/2019 - "Indirubin-based compounds affect diverse biological processes, such as inflammation and angiogenesis. "
05/30/2017 - "Indirubin alleviated LPS-caused oxidative stress and inflammation via reducing MDA abundance and IL-1β and TNF-α expressions in mice. "
05/01/2017 - "We found that indirubin reduced migration, invasion, inflammation, and proliferation in RA FLSs. "
10/01/2019 - "Indirubins E804 (indirubin-3'-(2,3 dihydroxypropyl)-oximether) and 7BIO (7-Bromoindirubin-3'-oxime) are synthetic derivatives of natural indirubin, the active compound in Danggui Longhui Wan, a traditional Chinese remedy for cancer and inflammation. "

01/01/1994 - "Indirubin from Indigofera tinctoria is useful for the treatment of chronic myelocytic leukemia. "
01/01/2015 - "The encouraging clinical results from the 1980s obtained in chronic myelocytic leukemia patients treated with indirubin stimulated numerous studies on this compound. "
10/01/1982 - "Studies on the mechanism of indirubin action in the treatment of chronic granulocytic leukemia. "
06/01/1980 - "[Studies on the mechanism of indirubin action in the treatment of chronic granulocytic leukemia. "
01/01/1979 - "[Clinical and experimental studies in the treatment of chronic granulocytic leukemia with indirubin (author's transl)]."

01/01/2018 - "Our results highlighted the novel mechanisms by which Indirubin ameliorates psoriasis-related inflammatory responses, supporting its therapeutic potential."
01/01/2022 - "To investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis. "
01/01/2018 - "This study aims to determine the immunoregulatory effects and the underlying mechanisms of Indirubin in psoriasis-related inflammatory responses. "
01/01/1987 - "[Clinical and ultrastructural study on psoriasis treated by indirubin]."
10/01/2023 - "Targeting upregulation of the immunosuppressive activity of MDSCs with indirubin as a novel strategy to alleviate psoriasis."

06/01/2018 - "In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). "
06/01/2018 - "In the model of acute colitis, indirubin treatment improved the loss of body weight. "
06/01/2018 - "Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease)."
01/01/2023 - "This study is aimed at clarifying the effect and mechanisms of the combined administration of indigo and indirubin on colitis mouse models. "
12/01/2023 - "Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice."