uridine 5'-monophosphate synthase (UMP synthase)

consists of orotate phosphoribosyltransferase EC & orotidylate decarboxylase EC
Also Known As:
UMP synthase; UMPS protein, human; Umps protein, mouse; Umps protein, rat; uridine 5'-monophosphate synthase, human; uridine 5'-phosphate synthase; uridine monophosphate synthetase, human; uridine monophosphate synthetase, mouse; uridine monophosphate synthetase, rat; uridylate synthase; Synthase, uridylate
Networked: 16 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Kraiklang, Ratthaphol: 1 article (01/2012)
2. Seubwai, Wunchana: 1 article (01/2012)
3. Wongkham, Sopit: 1 article (01/2012)
4. Wongkham, Chaisiri: 1 article (01/2012)
5. Frey, Alexandra: 1 article (01/2008)
6. Diederichsen, Ulf: 1 article (01/2008)
7. Gasow, Kathrin: 1 article (01/2008)
8. Wittmann, Julia G: 1 article (01/2008)
9. Heinrich, Daniel: 1 article (01/2008)
10. Rudolph, Markus G: 1 article (01/2008)

Related Diseases

1. Ascites
2. Carcinoma (Carcinomatosis)
11/15/1987 - "By using the placenta as a source of UMP synthase and by developing a novel purification procedure different from that used in the purification of UMP synthase from the Ehrlich ascites carcinoma (the only other homogeneous preparation of a mammalian UMP synthase), we achieved the purification of human UMP synthase to apparent homogeneity. "
11/15/1987 - "Earlier work of this laboratory showed that, in the mouse Ehrlich ascites carcinoma, both of these enzymatic activities were contained on the single multifunctional polypeptide chain, UMP synthase. "
11/15/1987 - "Preliminary characterization of the human placental UMP synthase showed it to be similar to UMP synthase from the Ehrlich ascites carcinoma in subunit molecular weight, native molecular weight, isozyme pattern (although not absolute pI values), pH optima of enzymatic activities, and kinetic constants for orotidine 5'-monophosphate (Km) and 6-azauridine 5'-monophosphate (Ki) at the decarboxylase site."
10/05/1982 - "Rabbit antibodies directed against homogeneous uridylate synthase multienzyme from mouse Ehrlich ascites carcinoma precipitate both the orotidine-5'-monophosphate decarboxylase (EC and orotate phosphoribosyltransferase (EC activities of mouse and human erythrocyte uridylate synthase. "
09/30/1980 - "UMP synthase, or multienzyme pyr-5,6 (orotate phosphoribosyltransferase:orotidine monophosphate decarboxylase), has been purified from Ehrlich ascites carcinoma to apparent homogeneity. "
3. Hepatocellular Carcinoma (Hepatoma)
4. Chromosome Breakage
5. Wounds and Injuries (Trauma)

Related Drugs and Biologics

1. Complementary DNA (cDNA)
2. Sucrose (Saccharose)
3. Messenger RNA (mRNA)
4. Orotate Phosphoribosyltransferase
5. pyrimidine
6. pyrazofurin
7. Tissue Extracts
8. Proteins (Proteins, Gene)
9. Ligases
10. Enzymes