chrysophanic acid

10/01/2020 - "Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway."
09/01/2017 - "In Nrf2+/+ mice, but not the Nrf2-/- animals, chrysophanol ameliorated metabolic disorders, improved cardiac function, reduced pathological changes, attenuated oxidative injury, down-regulated inflammatory response and fibrosis progression through regulating different signaling pathways. "
10/01/2022 - "Together, our work demonstrated for the first time that chrysophanol could effectively ameliorate renal fibrosis by inhibiting NKD2/NF-κB pathway. "
10/01/2022 - "The impact of chrysophanol on renal function, inflammation, fibrosis of CKD mice were evaluated. "
10/01/2022 - "Chrysophanol could significantly improve the kidney dysfunction, alleviate renal pathology, and reverse the elevated levels of renal fibrosis markers such as FN1, collagen ɑI and α-SMA. "

10/12/2020 - "CONCLUSIONS Chrysophanol improved cardiac functions and protected against myocardial damage, apoptosis, OS, and inflammation by inhibiting activation of the JNK1/2 pathway in AHF rat models. "
10/01/2022 - "In vitro studies, the inhibition on inflammation and fibrogenesis by chrysophanol was further validated in TGF-β1-stimulated HK2 cells, and the regulation of chrysophanol on NKD2/NF-κB pathway was analyzed. "
04/01/2018 - "Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice."
09/06/2016 - "Chrysophanol (CHR), a purified active constituent from rhubarb, possesses many biological activities including anti-inflammation. "
01/01/2014 - "Chrysophanol is an extract from plants of Rheum genus and it possesses many pharmacological effects including its anti-inflammation activity. "

01/01/2018 - "In this study, we tried to identify the anti-obesity effects of chrysophanol by using high-fat diet (HFD)-induced rats as in vivo models. "
01/01/2018 - "Though several studies have indicated numerous features of chrysophanol, no study has yet reported the effect of chrysophanol on juvenile obesity. "
01/01/2020 - "However, whether chrysophanol can mitigate obesity, and its underlying mechanisms remains unclear. "
01/01/2018 - "Chrysophanol ameliorates high-fat diet-induced obesity and inflammation in neonatal rats."
01/01/2020 - "In conclusion, this study demonstrated that chrysophanol can activate brown fat through the SIRT6/AMPK pathway and increase energy consumption, insulin sensitivity, and heat production, thereby alleviating obesity and metabolic disorders."

01/01/2019 - "The findings of the present study suggest that chrysophanol may prove beneficial in the treatment of malignant meningioma of optic nerve. "
12/01/2021 - "In addition, osteoglycin (OGN) may help mediate the antitumor effects of chrysophanol; thus, this study investigated the potential antitumor mechanism of chrysophanol in malignant meningioma cultures. "
01/01/2019 - "Key Message: The study revealed the anticancer potential of chrysophanol against the malignant optic nerve meningioma."
01/01/2019 - "However, there are no studies regarding the anticancer effects of chrysophanol against the malignant meningioma of optic nerve. "
12/01/2021 - "Chrysophanol may be useful as a treatment against malignant meningioma by inhibiting OGN/mTOR signaling and activating NF2 signaling."

01/01/2014 - "In this study, the effects of chrysophanol in cerebral ischemia/reperfusion and the potential mechanisms were investigated. "
06/01/2022 - "Effects of chrysophanol on hippocampal damage and mitochondrial autophagy in mice with cerebral ischemia reperfusion."
09/01/2018 - "Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion."
01/05/2018 - "Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice."
11/01/2022 - "Chrysophanol postconditioning attenuated cerebral ischemia-reperfusion injury induced NLRP3-related pyroptosis in a TRAF6-dependent manner."