bile acid-CoA amino acid N-acyltransferase

expressed in hepatocytes, sinusoidal endothelial cells and the Kupffer cells of the liver; may play a role in acute-phase reactions

Also Known As:

BAAT protein, human; Baat protein, mouse; Baat protein, rat; Kan-1 protein, rat; bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase), human; bile acid-Coenzyme A: amino acid N-acyltransferase, mouse; bile acid-coenzyme A amino acid N-acyltransferase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - bile acid-CoA amino acid N-acyltransferase: 5

Experts

1.	Chen, Yen-Hsu: 1 article (07/2007)
2.	Hong, I-Chu: 1 article (07/2007)
3.	Hsu, Chin: 1 article (07/2007)
4.	Hsu, Hseng-Kuang: 1 article (07/2007)
5.	Kuo, Kung-Kai: 1 article (07/2007)

Related Diseases

1.	Sepsis (Septicemia) 07/01/2007 - "Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis." 10/01/1995 - "Reduced expression of kan-1 (encoding putative bile acid-CoA-amino acid N-acyltransferase) mRNA in livers of rats after partial hepatectomy and during sepsis." 07/01/2007 - "Expression of rat hepatic bile acid coenzyme A-amino acid N-acyltransferase (rBAT), a major enzyme for the conjugation of bile acids, is significantly decreased during sepsis. "
2.	Cerebrotendinous Xanthomatosis 01/01/2023 - "Except for cerebrotendinous xanthomatosis and some secondary defects, various inborn errors of bile acid metabolism (IEBAM) have been reported from Japan, affecting eight patients including three with 3β-hydroxy-Δ5 -C27 -steroid dehydrogenase/isomerase deficiency, three with Δ4 -3-oxosteroid 5β-reductase deficiency, one with oxysterol 7α-hydroxylase deficiency, and one with bile acid-CoA: amino acid N-acyltransferase deficiency. "
3.	Neoplasms (Cancer) 02/21/2023 - "We also identified bile acid-CoA:amino acid N-acyltransferase (BAAT) by gene set enrichment analysis, which dominates the final step in the synthesis of conjugated bile acids associated with the inflammatory-cancer transformation process. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/1996 - "kan-1 (bile acid CoA:amino acid N-acyltransferase) messenger RNA as a novel predictive indicator for prognosis of hepatocellular carcinoma patients after partial hepatectomy."

Related Drugs and Biologics

1.	Bile Acids and Salts (Bile Acids)
2.	Messenger RNA (mRNA)
3.	Retinoid X Receptor alpha
4.	Steroids
5.	Oxidoreductases (Dehydrogenase)
6.	Isomerases
7.	Indicators and Reagents (Reagents)
8.	Enzymes
9.	Oxysterols

Related Therapies and Procedures

1.	Hepatectomy