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protein kinase NII

aspect of EC 2.7.1.37; phosphorylates basic non-histone proteins; cyclic nucleotide-independent

Also Known As:

wheat germ chromatin kinase NII

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        protein kinase NII: 5

Related Diseases

1.	Autoimmune Diseases (Autoimmune Disease) 02/25/1984 - "Anti-protein kinase NII antibodies in rheumatic autoimmune diseases." 07/05/1983 - "Antibodies against both RNA polymerase I and protein kinase NII were present in sera of patients with certain rheumatic autoimmune diseases. " 01/01/1983 - "These observations indicate that (1) the NII kinase can regulate RNA polymerase I activity, (2) protein kinase NII is associated with the polymerase I enzyme complex, and (3) certain polypeptides of this enzyme complex may be the target antigens in rheumatic autoimmune disease."
2.	Hepatocellular Carcinoma (Hepatoma) 11/10/1981 - "Activation of purified hepatoma RNA polymerase I by homologous protein kinase NII." 01/01/1983 - "In contrast to the purified hepatoma enzyme, RNA polymerase I activity in nuclear lysates was not affected by addition of protein kinase NII. "
3.	Experimental Liver Neoplasms 11/10/1981 - "We have recently purified a cyclic nucleotide-independent, heparin-sensitive nuclear protein kinase (NII) from Morris hepatoma 3924A and demonstrated an apparent relationship of this kinase to the two subunits (Mr = 42,000 and 24,600) of RNA polymerase I. When homogeneous protein kinase NII was recombined with purified homologous RNA polymerase I containing limiting quantities of endogenous kinase, RNA synthesis was stimulated as much as 5-fold during a 90-min incubation. "

Related Drugs and Biologics

1.	RNA Polymerase I (Polymerase I, RNA)
2.	Phosphotransferases (Kinase)
3.	Enzymes
4.	Antibodies
5.	RNA (Ribonucleic Acid)
6.	Peptides (Polypeptides)
7.	Cyclic Nucleotides
8.	Nuclear Proteins (Protein, Nuclear)
9.	Heparin (Liquaemin)
10.	Antigens