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isobutylcarbonyllactyl anhydride

inhibitor of lactate transport; structure in first source

Also Known As:

IBCLA; Propanoic acid, 2-(((2-methylpropoxy)carbonyl)oxy)-, anhydride with 2-methylpropyl carbonate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Lactates: 140
      - isobutylcarbonyllactyl anhydride: 1

Related Diseases

1.	Ehrlich Tumor Carcinoma 08/05/1980 - "When glycolyzing Ehrlich ascites tumor cells were treated with concentrations of iBCLA sufficient for complete inhibition of lactate transport, intracellular lactate levels increased, intracellular pH and extra-cellular lactate levels decreased, and overall lactate production was inhibited." 08/05/1980 - "In contrast, 15 microgram of iBCLA/mg of protein is required for 50% inhibition of phosphate transport in erythrocytes, and phosphate transport in Ehrlich ascites tumor cells is unaffected at levels as high as 50 microgram of iBCLA/mg of protein. "
2.	Ascites 08/05/1980 - "A time-dependent and concentration-dependent reversal of lactate transport inhibition took place on exposure of iBCLA-treated Ehrlich ascites cells to hydroxylamine or dithiothreitol. "

Related Drugs and Biologics

1.	Hydroxylamine (Hydroxylamine Hydrochloride)
2.	Lactic Acid (Lactate)
3.	Proteins (Proteins, Gene)
4.	Phosphates (Orthophosphate)
5.	Dithiothreitol (Cleland's Reagent)