dynorphin (1-8)

opioid octapeptide from porcine hypothalamus; comprises the N-terminal eight residues of dynorphin

Also Known As:

L-Isoleucine, N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-; L-Isoleucine, N-(N2-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-; PH-8P; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile; dynorphin A (1-8); tyrosyl-glycyl-glycyl-phenylalanyl--leucyl-arginyl-arginyl-isoleucine; alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-9-de-L-proline-10-de-L-lysine-

Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Dynorphins: 819
        dynorphin (1-8): 13
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Dynorphins: 819
        dynorphin (1-8): 13
  - Peptide Fragments: 373
    - dynorphin (1-8): 13

Experts

1.	Iadarola, Michael J: 1 article (09/2020)
2.	Kim, Jenny J: 1 article (09/2020)
3.	Loydpierson, Amelia J: 1 article (09/2020)
4.	Mannes, Andrew J: 1 article (09/2020)
5.	Maric, Dragan: 1 article (09/2020)
6.	Sapio, Matthew R: 1 article (09/2020)
7.	Thierry-Mieg, Danielle: 1 article (09/2020)
8.	Thierry-Mieg, Jean: 1 article (09/2020)
9.	Abbruscato, Thomas J: 1 article (04/2014)
10.	Arumugam, Thiruma V: 1 article (04/2014)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 04/01/1991 - "This study examined whether a relationship exists between the degree of dopamine (DA) loss and the changes in opioid (Met5-enkephalin, ME; dynorphin A (1-8) (DYN)) or tachykinin (substance P, SP) peptidergic systems in basal ganglia (caudate and putamen) and limbic (frontal cortex) regions of postmortem tissue samples derived from patients who died of Parkinson's disease (PD). "
2.	Hypertension (High Blood Pressure) 11/01/1990 - "Hippocampal levels of dynorphin A (1-8) in neonatal and 16-week-old spontaneously hypertensive rats: comparisons with DOCA-salt hypertension." 11/01/1990 - "In this study the possible role of hippocampal dynorphin in the development of hypertension in spontaneously hypertensive rats (SHR) was investigated by determining dynorphin A (1-8) (DN A (1-8] levels in hippocampus in 16 week old SRH, Wistar Kyoto (WKY) controls and SHR treated with antihypertensive drugs as well as DOCA-salt hypertensive Sprague Dawley (SD) rats, using radioimmunoassay (RIA). "
3.	Bulimia (Binge Eating) 02/01/1991 - "Measurement of CSF dynorphin A 1-8 immunoreactivity in anorexia nervosa and normal-weight bulimia." 02/01/1991 - "Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. "
4.	Feeding and Eating Disorders (Eating Disorder) 02/01/1991 - "These results regarding dynorphin A 1-8 immunoreactivity are discussed in light of other evidence for altered opiate function in some eating-disorder patients." 02/01/1991 - "Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. "
5.	Anorexia Nervosa 02/01/1991 - "Measurement of CSF dynorphin A 1-8 immunoreactivity in anorexia nervosa and normal-weight bulimia." 02/01/1991 - "Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. "

Related Drugs and Biologics

1.	Dynorphins (Dynorphin)
2.	Substance P
3.	Opioid Analgesics (Opioids)
4.	Desoxycorticosterone Acetate (DOCA)
5.	Tachykinins
6.	Salts
7.	Enkephalins
8.	Dopamine (Intropin)
9.	Antihypertensive Agents (Antihypertensives)
10.	Leucine Enkephalin