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2-tyrosine

RN given refers to cpd with unspecified isomeric designation

Also Known As:

2-hydroxyphenylalanine; 2-tyrosine, (D)-isomer; 2-tyrosine, (DL)-isomer; 2-tyrosine, (L)-isomer; ortho-tyrosine

Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Tyrosine: 10509
        2-tyrosine: 15

Experts

1.	Wittmann, István: 4 articles (01/2016 - 11/2005)
2.	Chiarella, Paula: 3 articles (01/2015 - 11/2011)
3.	Meiss, Roberto P: 3 articles (01/2015 - 11/2011)
4.	Ruggiero, Raúl A: 3 articles (01/2015 - 11/2011)
5.	Laczy, Boglárka: 3 articles (09/2014 - 11/2005)
6.	Csontos, Csaba: 2 articles (01/2020 - 01/2016)
7.	Miseta, Attila: 2 articles (01/2020 - 01/2016)
8.	Kun, Szilárd: 2 articles (01/2016 - 09/2014)
9.	Sélley, Eszter: 2 articles (01/2016 - 09/2014)
10.	Mikolás, Esztella: 2 articles (09/2014 - 08/2011)

Related Diseases

1.	Diabetes Mellitus 11/01/2005 - "Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production." 10/01/2014 - "Previous studies have shown that in diabetes mellitus, insulin-induced relaxation of arteries is impaired and the level of ortho-tyrosine (o-Tyr), an oxidized amino acid is increased. "
2.	Chronic Renal Insufficiency 11/01/2005 - "The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on the renal handling of the different tyrosine isomers and, furthermore, to measure urinary levels of 8-epi-prostaglandin-F(2alpha), a marker of lipid peroxidation. "
3.	Insulin Resistance 08/01/2011 - "After the fourth week, resveratrol significantly decreased insulin resistance (homeostasis model of assessment for insulin resistance) and urinary ortho-tyrosine excretion, while it increased the pAkt:Akt ratio in platelets. " 08/01/2011 - "Before and after the second and fourth weeks of the trial, insulin resistance/sensitivity, creatinine-normalised ortho-tyrosine level in urine samples (as a measure of oxidative stress), incretin levels and phosphorylated protein kinase B (pAkt):protein kinase B (Akt) ratio in platelets were assessed and statistically analysed. "
4.	Neoplasms (Cancer) 03/01/2012 - "In 3 different murine models of cancer that generate CR, both meta- and ortho-tyrosine inhibited tumor growth. " 11/15/2011 - "In three different murine models of cancer that generate CR, both meta-tyrosine and ortho-tyrosine inhibited tumor growth. " 01/01/2015 - "In a recent paper, we identified that elusive factor(s) as an equi-molar mixture of meta-tyrosine and ortho-tyrosine, two isomers of tyrosine that are not present in normal proteins and that proved to be responsible for 90% and 10%, respectively, of the total serum anti-tumor activity. " 01/01/2021 - "Apatinib, a selective vascular endothelial growth factor receptor 2-tyrosine kinase inhibitor, has demonstrated activity against a wide range of solid tumors, including advanced hepatocellular carcinoma (HCC). "
5.	Renal Insufficiency (Renal Failure) 11/01/2005 - "Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production."

Related Drugs and Biologics

1.	Tyrosine (L-Tyrosine)
2.	Insulin (Novolin)
3.	Amino Acids
4.	Incretins
5.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
6.	Creatinine
7.	3-tyrosine
8.	dityrosine
9.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
10.	Isoprostanes