|1.||Parsa, Arya: 1 article (07/2014)|
|2.||Thein, Pru: 1 article (07/2014)|
|3.||Urrutia, Raul: 1 article (07/2014)|
|4.||Kalinec, Gilda M: 1 article (07/2014)|
|5.||Kalinec, Federico: 1 article (07/2014)|
|6.||Yorgason, Joshua: 1 article (07/2014)|
|7.||Luxford, William: 1 article (07/2014)|
|8.||Merrill, Gary F: 1 article (10/2013)|
|9.||Schunke, Kathryn J: 1 article (10/2013)|
|10.||Denhardt, David T: 1 article (10/2013)|
09/01/1993 - "4-Aminophenol (PAP) is known to cause nephrotoxicity in the rat where it produces selective necrosis to renal proximal tubules. "
09/01/1990 - "1. The p-aminophenol (pAP) model of tubular necrosis displays elevated tubular pressures equivalent to 'stop-flow', with low glomerular filtration rate (GFR) but maintained blood flow and urine output. "
12/01/1983 - "Early functional and morphological changes in renal tubular necrosis due to p-aminophenol."
01/18/1969 - "Necrosis of the terminal third of the proximal convulated tubule develops in rats after a single intravenous injection of p-aminophenol hydrochloride. "
07/01/1992 - "p-Aminophenol causes necrosis of the pars recta of the proximal tubules in rats, and its nephrotoxicity may be due to glutathione-dependent bioactivation reactions. "
12/01/2009 - "The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats."
06/01/1947 - "The metabolic fate of acetanilid and other aniline derivatives; the role of p-aminophenol in the production of methemoglobinemia after acetanilid."
12/01/2009 - "We hypothesized that para-aminophenol (PAP) rather than NAPQI induces methemoglobinemia and that deficient arylamine N-acetyltransferase (NAT) activity in dogs and cats contributes to this species-dependent methemoglobinemia. "
10/01/1985 - "The suppression of methemoglobinemia by DTC and CS2 may result from an inhibition of metabolic conversion of p-phenetidine to methemoglobin-forming substances such as N-hydroxy-p-phenetidine which is of most importance, p-aminophenol and 2-hydroxy-p-phenetidine by the microsomal cytochrome P-450-containing monooxygenase system in the liver."
09/01/1987 - "To determine the relative contributions of these aniline metabolites to aniline-induced methemoglobinemia in rats, we determined time courses of methemoglobinemia in rat erythrocyte suspensions and in rats after treatment with 2- and 4-aminophenol, phenylhydroxylamine, and aniline. "
01/01/2013 - "Both 4-aminophenol and HMBA displayed antinociceptive activity in various rodent pain tests. "
07/01/2014 - "Pain relievers containing N-acetyl-para-aminophenol, also called APAP, acetaminophen or paracetamol, in combination with opioid narcotics are top-selling pharmaceuticals in the U.S. "
03/01/2001 - "In the therapy of pain of weaker genesis, frequently used drugs usually represent a mix of analgoantipyretics of different chemical structures, mostly derivatives of salicylic acid, pyrazolone and p-aminophenol as well as derivatives of propionic and acetylsalicylic acid. "
06/11/2012 - "Among these catalysts, the PtPd-based composites exhibited the highest activity and resistance to poisoning during the catalytic reduction of 4-nitrophenol to 4-aminophenol by NaBH(4). "
10/01/1989 - "4-Dimethylaminophenol (DMAP), an antidote in cyanide poisoning, has been shown to produce kidney lesions in rats, to damage isolated rat kidney tubules and to impair mitochondrial functions as already described for 4-aminophenol. "
07/08/1998 - "It was recently reported that p-aminophenol (p-AP) induces DNA cleavage in mouse lymphoma cells, CHO cells and human lymphoblastoid cells. "
01/01/1995 - "Genotoxic effects of p-aminophenol in Chinese hamster ovary and mouse lymphoma cells: results of a multiple endpoint test."
01/01/1995 - "p-Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. "
|2.||aniline (aniline hydrobromide)
|4.||Glutathione (Reduced Glutathione)
|10.||Salicylic Acid (2 Hydroxybenzoic Acid)