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stirocainide
structure in first source; RN given refers to fumarate salt
Also Known As:
2-benzal-1-((2'-diisopropylamino)ethoxyimino)cycloheptane hydrogen fumarate; TH 494; TH-494; Cycloheptanone, 2-(phenylmethylene)-, O-(2-(bis(1-methylethyl)amino)ethyl)oxime, (E)-2-butenedioate (1:1)
Networked:
2
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Ethanolamines: 16
stirocainide: 2
Alcohols: 595
Ethanol: 23169
Ethanolamines: 16
stirocainide: 2
Amino Alcohols: 20
Ethanolamines: 16
stirocainide: 2
Experts
1.
Cai, Xiaohong
: 1 article (05/2008)
2.
Duan, Jianxin
: 1 article (05/2008)
3.
Hart, Charles P
: 1 article (05/2008)
4.
Matteucci, Mark G
: 1 article (05/2008)
5.
Meng, Fanying
: 1 article (05/2008)
Related Diseases
1.
Anterior Wall Myocardial Infarction
01/01/1984 - "
The present study was undertaken to investigate the efficacy of the new antiarrhythmic compound stirocainide (2-(1-benzylidene)cycloheptenimino-oxyethyl-diisopropylamine -2-butenedionate, Th 494) in suppressing "2nd phase arrhythmias" arising from large anteroseptal myocardial infarctions using a standardized experimental canine preparation.
"
2.
Tachycardia (Tachyarrhythmias)
01/01/1984 - "
frequent ventricular ectopics, tachycardias, salvos, and R-on-T phenomena--are reduced by 80-90% (sometimes even completely abolished) by stirocainide (dose: 4 mg/kg within 3 min, followed by 300 micrograms/kg X min over a 20-min period).
"
3.
Pancreatic Neoplasms (Pancreatic Cancer)
05/01/2008 - "
Three lead compounds, TH-337, TH-482 and TH-494, exhibit potent antiproliferative activity against cell lines derived from human pancreatic carcinoma, human breast adenocarcinoma and human colorectal adenocarcinoma cells.
"
4.
Myocardial Infarction
01/01/1984 - "
Thus, Th 494 is a highly effective antiarrhythmic agent in acute myocardial infarction, and further experimental and clinical investigations on its antiarrhythmic and antifibrillatory properties may lead to beneficial therapeutic results.
"
01/01/1984 - "
Antiarrhythmic effects of stirocainide in acute myocardial infarction.
"
5.
Adenocarcinoma
05/01/2008 - "
Three lead compounds, TH-337, TH-482 and TH-494, exhibit potent antiproliferative activity against cell lines derived from human pancreatic carcinoma, human breast adenocarcinoma and human colorectal adenocarcinoma cells.
"