|1.||Liu, Jian: 4 articles (05/2013 - 08/2002)|
|2.||Drummond, Daryl C: 3 articles (12/2011 - 07/2006)|
|3.||Noble, Charles O: 3 articles (12/2011 - 07/2006)|
|4.||Park, John W: 3 articles (12/2011 - 07/2006)|
|5.||Errington, R J: 3 articles (11/2011 - 01/2005)|
|6.||Smith, P J: 3 articles (11/2011 - 01/2005)|
|7.||Vidaur, Fernando: 3 articles (09/2007 - 11/2005)|
|8.||Amondarain, José Antonio: 3 articles (09/2007 - 11/2005)|
|9.||Stewart, Clinton F: 3 articles (01/2007 - 03/2002)|
|10.||Quesada, Piera: 2 articles (04/2015 - 01/2011)|
02/01/2008 - "In the treatment study, both eyes of TPT-treated mice demonstrated significant reduction in tumor burden compared with both eyes of mice treated with FS only (59% reduction; P = 0.04). "
01/01/2007 - "These more "matured" vessels facilitated improved tumor TPT penetration (51.2% +/- 4.2%) compared with controls (30.8% +/- 4.7%, P = .004). "
01/15/2011 - "Pharmacokinetic and tumor-response studies, including analyses of ocular and hematopoietic toxicity, revealed that CBP(subcon)/TPT(syst) was more effective and had fewer side effects than TPT(subcon)/CBP(syst). "
01/01/2006 - "Further studies are needed to explore the role of MRP4 in resistance to, toxicity and pharmacokinetics of TPT in cancer patients."
05/01/2005 - "The results of biodistribution studies in S180 tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. "
01/01/2014 - "[Results] After 2 months, the six-minute walk test (6MWT), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and SF-36 testing showed significant improvement in both groups, but the improvement of the TPT group was greater. "
06/01/2008 - "Voix pedis' swelling and arthritis index in XFC, MTX and TPT groups were all obviously improved as compared with the untreated group. "
01/01/2012 - "To observe the effects of tripterygium glycosides tablet (TPT) on swelling degree, arthritis index (AI), pulmonary function, cytokines, the expression of regulatory T cells (Treg), and Foxp3 in rats of adjuvant arthritis. "
|3.||Ovarian Neoplasms (Ovarian Cancer)
11/01/2005 - "This study investigates the role of BCRP in resistance of ovarian cancer to TPT treatment. "
03/01/2004 - "A TPT-resistant ovarian cancer cell line A2780/TPT established in this laboratory was used in this study. "
01/01/2015 - "Our findings suggest that the addition of CHEK1 inhibitor increases the response of ovarian cancer cells to TPT. "
01/01/2015 - "When combined with CHEK1 inhibitor, TPT potently and synergistically inhibited the proliferation of HGS ovarian cancer cells. "
01/01/2015 - "Non-HGS ovarian cancer cells were generally more sensitive to TPT treatment compared to HGS ovarian cancer cells. "
|4.||Brain Neoplasms (Brain Tumor)
07/01/2006 - "We conclude that the combination of a novel nanoparticle Ls-TPT and CED administration was very effective in treating experimental brain tumors."
01/01/2007 - "In this study, we evaluated a combination of nanoliposomal topotecan (nLs-TPT) and pegylated liposomal doxorubicin (PLD) to enhance efficacy in our brain tumor models, and to establish a CED treatment capable of improving survival from malignant brain tumors. "
08/01/1998 - "camptothecin (CPT) and topotecan (TPT), and chemotherapeutic agents known to be active in treatment of brain tumors, in vitro studies were conducted with human glioma and medulloblastoma cell lines. "
|5.||Body Weight (Weight, Body)
01/01/2012 - "The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. "
01/01/2010 - "In this study the effects of maternal exposure to TPT at doses of control (0), 1.875, 3.75, or 7.5 mg/kg body weight/d, po, were examined during gestation and lactation on offspring growth, organ weights, and fertility. "
12/01/2011 - "The body weight of the XFC group was significantly higher than those of the MTX- and TPT-treated groups. "
12/01/2007 - "Body weight was monitored to assess TPT-induced toxicity, and serial blood samples were collected and analyzed via HPLC to assess TPT pharmacokinetics. "
08/01/1991 - "In offspring, little effect of TPT on body weight, pinna detachment, incisor eruption, eye opening, surface righting, cliff avoidance, pivoting and negative geotaxis was found in either the 4 mg/kg or 8 mg/kg groups. "
|3.||Type I DNA Topoisomerases (Topoisomerase I)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|3.||Photochemotherapy (Photodynamic Therapy)