messenger ribonucleoprotein

01/01/2019 - "THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. "
02/01/2011 - "To understand the mechanisms that generate genome instability mediated by mRNP biogenesis impairment and by AID, we devised a yeast chromosomal system based on different segments of mammalian S regions and c-MYC for the analysis of chromosomal rearrangements in both wild-type and THO mutants. "
08/01/2010 - "The interplay between transcription and mRNP formation feeds forward and backward and involves a number of conserved factors, from THO to THSC/TREX-2, which in addition have a unique impact on transcription-dependent genome instability. "
10/01/2006 - "To get more insight into the interconnection between mRNP biogenesis and genomic instability, we searched for HPR1 mutations that differentially affect gene expression and recombination. "
04/01/2006 - "Our results link transcription-dependent genomic instability in THO mutants with impaired replication fork progression, suggesting a molecular basis for a connection between inefficient mRNP biogenesis and genetic instability."

06/29/1983 - "A few mRNAs in S-180 ascites cells are found as non-polysomal messenger ribonucleoprotein particles, whose translation is restricted both in vivo and in vitro. "
05/01/1983 - "In the present report we summarize recent results concerning our studies on messenger ribonucleoprotein particles and RNA-binding proteins from the cytoplasm of mouse erythroblasts and mouse Krebs II ascites cells."
08/25/1979 - "Distribution of cytoplasmic poly(A+)RNA sequences in free messenger ribonucleoprotein and polysomes of mouse ascites cells."
08/25/1979 - "Characterization of poly(A+)RNA in free messenger ribonucleoprotein and polysomes of mouse Taper ascites cells."
05/31/1979 - "Poly(A+)mRNA sequences in free mRNP and polysomes of mouse ascites cells."

02/17/2011 - "This study opens the possibility of defining mRNP biogenesis factors as putative players in cell proliferation that could contribute to tumor development."
11/15/2013 - "Therefore, our work demonstrates that mRNP factors are critical for genome integrity and opens the option of using them as therapeutic targets in anti-cancer treatment. "
02/17/2011 - "We show that the expression of two mRNP factors, THOC1 and ALY are altered in several tumor tissues. "
02/17/2011 - "Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers."
01/01/2023 - "Molecular and clinical evidence indicated that Fragile X Messenger Ribonucleoprotein 1 (FMRP) plays a role in different types of cancer, including breast cancer. "

01/01/2018 - "mRNP assembly, axonal transport, and local translation in neurodegenerative diseases."
01/01/2014 - "Analysis of mRNP granules in their various contexts has revealed common themes of assembly, disassembly, and modes of mRNA regulation, yet new studies continue to reveal unexpected and important findings, such as links between aberrant mRNP granule assembly and neurodegenerative disease. "
11/01/2023 - "The fragile X messenger ribonucleoprotein 1 (FMRP) is a multifunctional RNA-binding protein implicated in human neurodevelopmental and neurodegenerative disorders. "
01/01/2018 - "In this review, we discuss evidence that disturbances in mRNP transport, granule assembly, axonal localization, and local translation contribute to pathology in various neurodegenerative diseases, including spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD)."
01/01/2017 - "Two prominent examples are the RBPs TAR DNA-binding protein of 43 kDa (TDP-43) and fused in sarcoma (FUS), which form pathological messenger ribonucleoprotein aggregates in patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating neurodegenerative disorders. "

01/01/2021 - "Results: With activity stimulation and various molecular approaches, we further demonstrate activity-dependent mRNP granule dynamics involving disassembly of mRNP granules, release of mRNAs, activation of local protein translation, and the impairment of granule disassembly in cellular, animal and human models of TDP-43 proteinopathy. "
01/01/2021 - "Conclusion: Our study elucidates the interplay between TDP-43 and neuronal mRNP granules in normal physiology and TDP-43 proteinopathy in the regulation of local protein translation and mRNA metabolism in the postsynaptic compartment."
01/01/2021 - "TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism."