|1.||Getoff, Nikola: 1 article (01/2010)|
|2.||Quint, Ruth Maria: 1 article (01/2010)|
|3.||Gerschpacher, Marion: 1 article (01/2010)|
|4.||Hartmann, Johannes: 1 article (01/2010)|
|5.||Schittl, Heike: 1 article (01/2010)|
|6.||Huber, Johannes C: 1 article (01/2010)|
|7.||Jankowiak, R: 1 article (09/2003)|
|8.||Small, G J: 1 article (09/2003)|
|9.||Markushin, Y: 1 article (09/2003)|
|10.||Zhong, W: 1 article (09/2003)|
01/21/2010 - "4-Hydroxyestrone (4-OHE(1)), a typical cancer-inducing metabolite, originating from 17beta-estradiol (17beta-E2), was chosen as a model for the studies. "
04/01/2002 - "The finding of reduced UGT2B7 protein and glucuronidation of 4-hydroxyestrone in invasive cancers suggests a tumor-suppressor function for the enzyme. "
04/01/2002 - "Using reverse transcriptase-polymerase chain reaction, immunocytochemistry, immunoblot analyses, and assays of glucuronidation of 4-hydroxyestrone, we show that UGT2B7 is expressed in human mammary epithelium, and that its expression is dramatically reduced in invasive breast cancers. "
09/30/2002 - "Some results in this respect are available for stimulating tumor growth for the D-ring metabolite 16-hydroxyestrone and the A-ring metabolites 4-hydroxyestrone and 4-hydroxyestradiol. "
04/01/2002 - "Expression of UGT2B7, a UDP-glucuronosyltransferase implicated in the metabolism of 4-hydroxyestrone and all-trans retinoic acid, in normal human breast parenchyma and in invasive and in situ breast cancers."
|2.||Breast Neoplasms (Breast Cancer)
05/01/2000 - "Finally, the endogenous catechol estrogen metabolite 4-hydroxyestrone (4-OHE) was considerably less effective at inducing DNA damage and apoptosis in breast cancer cell lines than 4-OHEN. "
01/01/1999 - "Previous studies from this laboratory have suggested that 2-hydroxyestrone is protective against breast cancer, whereas the other principal metabolite, 16 alpha-hydroxyestrone, and the lesser metabolite quantitatively, 4-hydroxyestrone, are potent carcinogens. "
|4.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|8.||Glucuronosyltransferase (UDP Glucuronosyltransferase)
|9.||Tretinoin (Retinoic Acid)