|1.||Rosner, Bernard: 2 articles (11/2004 - 12/2003)|
|2.||Glynn, Robert J: 2 articles (11/2004 - 12/2003)|
|3.||Bhatnagar, A: 2 articles (01/2001 - 07/2000)|
|4.||Srivastava, S: 2 articles (01/2001 - 07/2000)|
|5.||Ruef, J: 2 articles (01/2001 - 07/2000)|
|6.||Park, Yong Seek: 1 article (07/2009)|
|7.||Sebastiani, Paola: 1 article (07/2009)|
|8.||Lorenzi, Mara: 1 article (07/2009)|
|9.||Gerhardinger, Chiara: 1 article (07/2009)|
|10.||Dagher, Zeina: 1 article (07/2009)|
|1.||Diabetic Neuropathies (Diabetic Neuropathy)
04/01/1988 - "There was no significantly beneficial effect of sorbinil on clinical or neurophysiological measurements of nerve function in patients with established diabetic neuropathy. "
04/01/1986 - "In a study of 11 patients with severely painful diabetic neuropathy treated with sorbinil for 3 weeks [placebo-controlled in single-blind fashion (n = 8)], pains (as assessed on a 0 to 20 rating scale) improved from a mean score of 16 down to 8, with deterioration following drug withdrawal. "
11/15/1985 - "After an improvement in motor and sensory nerve conduction velocities was demonstrated in asymptomatic diabetic patients taking sorbinil (compared with velocities during a placebo period), 11 patients with painful diabetic neuropathy were treated with sorbinil for three weeks without alterations in diabetic management or control. "
06/01/1985 - "It is concluded that sorbinil treatment results in some improvement in peripheral nerve function in symptomatic diabetic polyneuropathy, but that the long-term effect may be of limited value."
09/01/1988 - "In a double-blind placebo-controlled trial the effect of Sorbinil (250 mg daily) on diabetic neuropathy was examined. "
01/01/1994 - "ARIs have shown efficacy in slowing down and preventing the progression of experimental sugar cataracts; sorbinil can partially reverse the very early morphological signs of sugar cataract. "
03/01/1990 - "The lens water in untreated diabetic animals with cataracts did not differ from lens water in the Sorbinil-treated diabetic animals that did not develop cataracts. "
03/01/1989 - "We have been able to completely prevent cataract formation in diabetic degus using Pfizer's sorbinil for up to 6 months. "
03/01/1989 - "Cataract prevention in diabetic Octodon degus with Pfizer's sorbinil."
06/01/1985 - "However, Sorbinil had no significant effect on the enzyme activity following the establishment of mature cataracts."
07/01/1996 - "We conclude that in animals hyperglycemic long enough to slow NCV, sorbinil and/or ALC treatment reduces the functional, structural, and biochemical changes associated with hyperglycemia that occur in the myelin sheath."
09/01/1987 - "Thus, hyperviscosity per se is not responsible for the decreased deformability, and sorbinil can partially prevent this change despite persistent hyperglycemia. "
09/01/1987 - "The reduced deformability characterizing cells from diabetic rats and its partial prevention by sorbinil persisted even when RBCs were washed to eliminate hyperglycemia and hyperviscous plasma. "
09/01/1988 - "We conclude that sorbinil, as a metabolic intervention targeted against a specific biochemical consequence of hyperglycemia, can improve the neuropathologic lesions of diabetic neuropathy."
01/01/1986 - "Sorbinil treatment prevented approximately 70% of the increase in total protein excretion despite persistent hyperglycemia, glycosuria and ketonuria. "
01/01/1986 - "Two small preliminary studies in patients with painful neuropathy have shown that clinically significant reduction of pain was more frequently achieved with sorbinil than with placebo. "
10/01/1983 - "Among the many measurements, only pain, tendon reflex scores, and sural sensory potential amplitude improved significantly during sorbinil administration, while scores of clinical sensory examination deteriorated. "
06/01/1984 - "Subjective pain scores on a 10 cm visual analogue scale were 4.2 +/- 2.4 on placebo and 4.3 +/- 2.4 after sorbinil. "
|5.||Neurologic Manifestations (Neurological Manifestations)
|1.||Aldehyde Reductase (Aldose Reductase)
|10.||Blood Glucose (Blood Sugar)