fumagillin

09/01/2004 - "Exposure of one or two generations to fumagillin at 6000 ppm or higher eliminated infection in adult moths, but also reduced colony fitness. "
09/11/1998 - "Oral treatment with fumagillin is effective for controlling various microsporean and myxosporean infections in fish. "
01/01/1988 - "Efficacy of fumagillin against Myxidium giardi Cépéde, 1906 infection of the European eel (Anguilla anguilla): new observations on myxidiosis of imported glass eels."
10/01/2012 - "Studies were subsequently undertaken to evaluate the impact of Nosema infection on tarnished plant bug productivity and to test the efficacy of fumagillin to treat this infection. "
07/07/2000 - "This study was designed to assess the safety and efficacy of oral fumagillin in this infection. "

01/01/2021 - "Safety and efficacy of fumagillin for the treatment of intestinal microsporidiosis. "
06/01/2006 - "These results thus support continued studies to identify more effective fumagillin-related drugs for treating microsporidiosis."
11/01/1997 - "Our study allowed the identification of oral fumagillin as a potential treatment for intestinal microsporidiosis due to E. "
09/01/2018 - "bombycis and also towards the usage of Fumagillin in the control of microsporidiosis in B. "
01/01/2017 - "Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin"

01/01/1994 - "Microsporidial keratoconjunctivitis treated successfully with a short course of fumagillin."
09/01/1995 - "Although a curative agent has yet to be discovered, fumagillin represents a safe, effective, low-cost, topical agent for the treatment of microsporidial keratoconjunctivitis."
09/01/1995 - "To report microsporidial keratoconjunctivitis in a patient infected with HIV who was treated with topical fumagillin. "
03/15/1993 - "Treatment of microsporidial keratoconjunctivitis with topical fumagillin."
06/01/1996 - "The keratoconjunctivitis resolved after three weeks of therapy with topical fumagillin. "

08/01/2008 - "Fumagillin suppresses angiogenesis in cancer models and clinical trials, but it is associated with neurotoxicity at systemic doses. "
01/01/2023 - "Moreover, fumagillin treatment significantly decreased tumor formation in nude mice. "
02/01/2022 - "Collectively, our results demonstrate that MetAP2 is critical for VM in human cancer cells and suggest fumagillin and TNP‑470 as potent VM‑suppressing agents."
06/01/2020 - "Taken together, these uninherited-fumagillin compounds may serve as new class of inhibitors or provide scaffolds for further optimization towards the design of more potent MetAP2 inhibitors -development of such inhibitors would be essential strategy against various cancer types."
09/27/2016 - "Fumagillin and its derivatives are therapeutically useful because they can decrease cancer progression. "

04/01/2010 - "These studies on in vitro and in vivo preadipcoyte differentiation thus do not support an anti-obesity effect of fumagillin as a result of effects on adipocyte differentiation."
12/01/2010 - "Thus, treatment with fumagillin impaired diet-induced obesity in mice, associated with adipocyte hypotrophy but without marked effect on adipose tissue angiogenesis."
12/01/2010 - "Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity."
04/15/2016 - "The natural product fumagillin is a selective and potent irreversible inhibitor of MetAP2, and semisynthetic derivatives of fumagillin have shown promise in clinical studies for the treatment of cancer, and, more recently, for obesity. "
03/01/2015 - "Because adipose tissue can grow and regress throughout adulthood, is highly vascularized, and has angiogenic properties, interest in investigating anti-angiogenic agents in animal models of obesity found that fumagillin analogs caused dose-dependent reversible weight reduction and adipose tissue loss. "