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benzo(b)thiophene-2-carboxylic acid

for prevention of osteoporosis; structure given in first source

Also Known As:

BL 5583; BL-5583; thionaphthene-2-carboxylic acid; thionapthene-2-carboxylic acid

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - benzo(b)thiophene-2-carboxylic acid: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - benzo(b)thiophene-2-carboxylic acid: 3

Related Diseases

1.	Bone Resorption 12/01/1992 - "Thionaphthene-2-carboxylic acid (TNCA) has been shown to decrease osteoclast-mediated bone resorption in vitro and has shown efficacy in animal models of hypercalcaemia of malignancy. " 10/01/1985 - "We have compared TCA with thionapthene-2-carboxylic acid (TNCA), an analog which is a more potent inhibitor of bone resorption in vitro, for the ability to decrease serum calcium concentration in vivo. " 03/01/1984 - "BL-5583, at a dose range of 0.01-100 micrograms/ml, inhibited spontaneous as well as A23187 and PTH-induced bone resorption in tissue culture. "
2.	Neoplasms (Cancer) 12/01/1992 - "Thionaphthene-2-carboxylic acid (TNCA) has been shown to decrease osteoclast-mediated bone resorption in vitro and has shown efficacy in animal models of hypercalcaemia of malignancy. "

Related Drugs and Biologics

1.	Calcium
2.	Calcimycin (A23187)