prolyl- phenylalanyl- arginine- 4- nitroanilide

chromogenic cpd

Also Known As:

D-prolyl-L-phenylalanyl-N-(4-nitrophenyl)-L-argininamide; H-D-Pro-Phe-Arg-p-nitroanilide; H-D-prolyl-phenylalanyl-arginine-para-nitroanilide; Pro-Phe-Arg-p-nitroanilide; S-2302; S-2648; prolyl-phenylalanyl-arginine-4-nitroanilide dihydrochloride; prolyl-phenylalanyl-arginine-p-nitroanilide; L-Argininamide, D-prolyl-L-phenylalanyl-N-(4-nitrophenyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - prolyl-phenylalanyl-arginine-4-nitroanilide: 5

Experts

1.	Funauchi, M: 1 article (01/2000)
2.	Ikoma, S: 1 article (01/2000)
3.	Matsuura, K: 1 article (01/2000)
4.	Sinohara, H: 1 article (01/2000)
5.	Sugiyama, M: 1 article (01/2000)

Related Diseases

1.	Periodontitis 01/01/1998 - "Trypsin-like activity was also found to be significantly raised in periodontitis compared to normals when Pro-Phe-Arg-p-nitroanilide (0.666±0.204 units/mg protein), Ile-Pro-Arg-p-nitroanilide (1.59±0.260 units/mg protein) and Pyroglu-Pro-Arg-p-nitroanilide (1.82±0.380 units/mg protein) were used as substrates. "
2.	Nephrotic Syndrome (Syndrome, Nephrotic) 09/01/1983 - "A distinct increase of kallikrein content in blood plasma of patients with nephrotic syndrome as well as activation of thrombin simultaneously with a decrease in the prothrombin level were recorded in samples with synthetic chromogenic substrates S-2160 (Bz-Phe-Val-Arg-pNa), S-2238 (D-Phe-Pip-Arg-pNA) and S-2302 (D-Pro-Phe-Arg-pNA). "
3.	Liver Diseases (Liver Disease) 11/15/1994 - "Generation of amidolytic activity towards the chromogenic substrate S-2302 after incubation with dextran sulphate (DXS), was found in ascites from patients with gastrointestinal cancer, but not in ascites from patients with benign liver disease. "
4.	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 11/15/1994 - "Generation of amidolytic activity towards the chromogenic substrate S-2302 after incubation with dextran sulphate (DXS), was found in ascites from patients with gastrointestinal cancer, but not in ascites from patients with benign liver disease. "
5.	Factor XII Deficiency 02/01/1983 - "In contrast, the mean concentration in five plasma samples from patients deficient in HMW kininogen was 0.38 +/- 0.02 S-2302 U/ml. No activity was generated in prekallikrein-deficient plasma, and essentially normal levels (1.35 +/- 0.18 S-2302 U/ml) were measured in plasmas from three patients with factor XII deficiency. "

Related Drugs and Biologics

1.	Chromogenic Compounds
2.	Trypsin
3.	Thrombin
4.	Prothrombin (Factor II)
5.	Proteins (Proteins, Gene)
6.	Prekallikrein
7.	Kininogens (Kininogen)
8.	Kallikreins (Kallikrein)
9.	Immunoglobulins (Immunoglobulin)
10.	Dextrans (Dextran)