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purpurogallin

oxidation product of pyrogallol; structure

Also Known As:

2,3,4,6-tetrahydroxy-5H-benzocyclohepten-5-one

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Benzocycloheptenes
        purpurogallin: 15
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Benzocycloheptenes
    - purpurogallin: 15

Experts

1.	Bode, Ann M: 1 article (01/2019)
2.	Chen, Hanyong: 1 article (01/2019)
3.	Dong, Zigang: 1 article (01/2019)
4.	Kim, Dong Joon: 1 article (01/2019)
5.	Liu, Fangfang: 1 article (01/2019)
6.	Liu, Feifei: 1 article (01/2019)
7.	Liu, Kangdong: 1 article (01/2019)
8.	Wang, Penglei: 1 article (01/2019)
9.	Wang, Ting: 1 article (01/2019)
10.	Wang, Xiangyu: 1 article (01/2019)

Related Diseases

1.	Necrosis 10/01/1994 - "The addition of purpurogallin (0.25 or 1.0 mM) significantly increased time to cell necrosis to 8.18 +/- 0.83 and 11.59 +/- 1.71 minutes respectively (p < 0.05). " 11/01/1994 - "The results demonstrated that purpurogallin at 1.0 mM delayed cell necrosis to 9.98 +/- 1.16 min compared with 2.96 +/- 0.67 min without antioxidant protection. " 08/01/1992 - "At levels equimolar to purpurogallin, either Trolox or allopurinol is less effective in delaying cell necrosis. " 10/01/1994 - "We examined the protective properties of purpurogallin, a naturally occurring phenol, in delaying necrosis of cultured corneal endothelial cells caused by oxygen free radicals. "
2.	Neoplasms (Cancer) 01/01/2019 - "Notably, purpurogallin suppressed patient-derived ESCC tumor growth in an in vivo mouse model. " 05/01/2019 - "Cytotoxicity assays had proved that purpurogallin carboxylic acid had an inhibitory effect towards breast (MCF7) and lung (A549) cancer cell lines. "
3.	Neuroinflammatory Diseases 10/01/2022 - "Purpurogallin improves neurological functions of cerebral ischemia and reperfusion mice by inhibiting endoplasmic reticulum stress and neuroinflammation." 01/01/2014 - "In conclusion, purpurogallin exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression. "
4.	Corneal Endothelial Cell Loss 02/01/1998 - "Morin hydrate: a better protector than purpurogallin of corneal endothelial cell damage induced by xanthine oxidase and SIN-1."
5.	Atherosclerosis 12/01/2010 - "Many natural products, including vitamin E, garlic, purpurogallin, flaxseed and its components [secoisolariciresinol diglucoside (SDG) and flax lignan complex (FLC)] and resveratrol have been reported to suppress hypercholesterolemic atherosclerosis. "

Related Drugs and Biologics

1.	Allopurinol (Remid)
2.	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)
3.	Phenol (Carbolic Acid)
4.	Flavonoids
5.	MAP Kinase Kinase 1
6.	TNF Receptor-Associated Factor 6 (TRAF6)
7.	HMGB1 Protein (HMG1)
8.	Lignans
9.	Interleukin-6 (Interleukin 6)
10.	Xanthine Oxidase