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N(6)- (2- (4- chlorophenyl)bicyclo(2.2.2.)- octyl)(3)- adenosine

enhances diazepam binding to brain benzodiazepine receptors

Also Known As:

EMD 28422; EMD-28422; Adenosine, N-(3-(4-chlorophenyl)bicyclo(2.2.2)oct-2-yl)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        N(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - N(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine: 1
  - Ribonucleosides: 49
    - Adenosine: 12431
      - N(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine: 1

Related Diseases

1.

Seizures (Absence Seizure)

05/01/1980 - "This increase in (3H) diazepam binding is due to an increase in the number of benzodiazepine receptors (Bmax) rather than an altered affinity of the radioligand for receptor (Kd), EMD 28422 protects mice against pentylenetetrazole and caffeine-induced seizures and potentiates the anticonvulsant action of subeffective doses of diazepam in a dose-dependent fashion. "

Related Drugs and Biologics

1.	GABA-A Receptors (GABA(A) Receptor)
2.	Pentylenetetrazole (Metrazol)
3.	Diazepam (Valium)
4.	Caffeine (No Doz)
5.	Anticonvulsants (Antiepileptic Drugs)