propadiene

08/30/2016 - "Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells."
08/30/2016 - "A propadiene compound: 1-phenylpropadienyl phosphine oxide (PHPO), was employed to test the chemotherapeutic efficacy against ovarian cancer cell lines. "

01/01/2021 - "Mechanistic studies indicated that the reaction proceeded through allenol formation, azide-allene [3 + 2] cycloaddition, and dehydration. "
08/15/2021 - "The allene allyl carbocation in neoxanthin diesters was generated from dehydration after preferential protonation at the hydroxy group. "
01/12/1988 - "We propose that the biosynthesis of racemic cis-12-oxo-PDA proceeds by dehydration of the 13(S)-hydroperoxide to an allene oxide. "
12/01/2021 - "The P450 domains may also catalyze homolytic cleavage of 8- and 9-hydroperoxy fatty acids and dehydration to produce epoxides with an adjacent double bond, i.e., allene oxides, thus displaying 8- and 9-DOX-allene oxide synthases (AOS). "
07/01/2002 - "This enzyme catalyses dehydration of the hydroperoxide to an unstable allene oxide in the JA biosynthetic pathway. "

01/01/1989 - "In particular, 2-mercaptoethanol reacted with 4 to afford deschloro vinyl thioether 13 as suggested by NMR spectral studies, a result that implicated allene-quinone 14 as the electrophilic species produced in solution from 4. Antiestrogen binding sites and estrogen receptors from MCF 7 human breast cancer cells interacted with 3 and 5 with affinities comparable to those of tamoxifen and 1, respectively; 5 was shown not to bind irreversibly with these sites. "

09/01/2023 - "DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1-/- mice."
09/01/2023 - "This study demonstrated that an allene small molecule (DWL-4-140) can efficiently and selectively exert regulatory effects on the stimulator of interferon genes (STING), resulting in the downregulation of DNA-induced interferon responses. "

08/04/2021 - "We also discuss catalyst poisoning due to allene and designing a potential new catalyst tolerant towards allene poisoning."
09/06/2019 - "A new ligand, (6-Cl-3-Me-Py)PPh2 , is proposed, which is predicted to efficiently control the branched/linear selectivity, avoiding rapid poisoning (with only 0.2 % of propadiene being trapped as the Pd allyl complex), and to tremendously increase the catalytic activity by decreasing the overall barrier to 9.1 kcal mol-1 ."