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cannogenol-3-O-beta-D-allomethyloside

cardenolide from Convallaria majalis L.; structure in first source

Also Known As:

frugoside; card-20(22)-enolide, 3-((6-deoxy-D-allopyranosyl)oxy)-14,19-dihydroxy-, (3 beta,5 alpha)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        Digitoxin: 364
        Digitoxigenin: 31
        cannogenol-3-O-beta-D-allomethyloside: 2

Experts

1.	Fan, Kai: 1 article (10/2021)
2.	Hu, Aihau: 1 article (10/2021)
3.	Liu, Yan Li: 1 article (10/2021)
4.	Tan, Guanghong: 1 article (10/2021)
5.	Wang, Hao: 1 article (10/2021)
6.	Wang, Hua: 1 article (10/2021)
7.	Zeng, Xiangzhou: 1 article (10/2021)
8.	Zhang, Danyang: 1 article (10/2021)
9.	Zhang, Haiyan: 1 article (10/2021)
10.	Jang, Sung-Wuk: 1 article (06/2019)

Related Diseases

1.	Osteoarthritis 10/02/2021 - "Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization."
2.	Neoplasms (Cancer) 06/19/2019 - "In addition, we observed that frugoside inhibited tumor growth without toxicity through a M14 xenograft animal model. " 06/19/2019 - "The bioactive compound frugoside has been recently reported to inhibit growth when used in various cancer cells. "
3.	Melanoma (Melanoma, Malignant) 06/19/2019 - "Taken together, our findings reveal that frugoside exhibits a novel antitumor effect based on a ROS-mediated cell death in melanoma cells, which may have therapeutic implications." 06/19/2019 - "Frugoside Induces Mitochondria-Mediated Apoptotic Cell Death through Inhibition of Sulfiredoxin Expression in Melanoma Cells." 06/19/2019 - "Furthermore, frugoside increased the accumulation of sulfinic Prxs and reactive oxygen species (ROS) and stimulated p-p38 activation, resulting in the mitochondria-mediated death of M14 and A375 human melanoma cells. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)