saikosaponin D

09/01/2020 - "Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway."
01/01/2020 - "Saikosaponin D alleviates inflammation and regulates autophagy by inhibiting the PI3k/Akt/mTOR signaling pathway. "
07/01/2019 - "[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN]."
08/01/2016 - "However, saikosaponins (SS) as the main pharmacodynamic active ingredient, their pharmacological effects and action mechanism in anti-inflammation have not been reported frequently. "
07/01/2006 - "Saikosaponins isolated from medicinal plants such as Bupleurum spp., Heteromorpha spp. and Scrophularia scorodonia have been reported to possess various biological activities, specifically antihepatitis, antinephritis, antihepatoma, anti-inflammation, immunomodulation and antibacterial effects. "

02/25/2019 - "Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway."
09/01/2023 - "Saikosaponin A (SSA) protects against pressure overload‑induced cardiac fibrosis. "
12/01/2021 - "Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling."
02/01/2020 - "Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway."
01/01/2018 - "Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT."

02/01/2018 - "Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice."
01/18/2023 - "Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice."
02/01/2018 - "The purpose of this study was to investigate the protective effects of Saikosaponin a (SSa), a triterpene saponin derived from Radix bupleuri, on lipopolysaccharide (LPS)-induced acute lung injury (ALI) using a murine model. "
01/18/2023 - "(BC) and the protective effects of saikosaponin A (SSA), saikosaponin b1 (SSb1), saikosaponin b2 (SSb2), and saikosaponin D (SSD) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice. "

07/01/2019 - "Taken together, our results indicated that Saikosaponin A had protective effects against DSS-induced colitis. "
07/01/2019 - "Saikosaponin A protected DSS-induced colitis through inhibiting inflammatory response."
04/01/2020 - "Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice."
07/01/2019 - "The aim of this study was to investigate the effects of Saikosaponin A on dextran sulfate sodium (DSS)-induced colitis in mice. "
07/01/2019 - "Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice."

08/24/2023 - "Corrigendum to "Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway" Behav. "
01/01/2021 - "Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway."
01/01/2021 - "These results revealed that Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of BDNF, p-CREB and Bcl-2, as well as decreasing the level of Bax, Caspase-3."