primidolol

antihypertensive agent with both alpha & beta adrenoceptor blocking activity; RN & N1 from 9th CI Form Index; RN given refers to parent cpd; structure in UD 31;139f

Also Known As:

UK-11,443; primidolol hydrochloride; 2,4(1H,3H)-pyrimidinedione, 1-(2-((2-hydroxy-3-(2-methylphenoxy)propyl)amino)ethyl)-5-methyl-, monohydrochloride

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Propanolamines: 4
      - primidolol: 2
- Alcohols: 595
  - Amino Alcohols: 20
    - Propanolamines: 4
      - primidolol: 2
  - Propanols: 3
    - Propanolamines: 4
      - primidolol: 2

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/1980 - "Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension." 01/01/1980 - "A study was carried out in 15 adult in-patients with moderately severe hypertension to investigate the efficacy and safety of single and twice daily doses of primidolol (UK-11,443), a new antihypertensive agent with both alpha- and beta-adrenoceptor blocking activity. "
2.	Vertigo (Positional Vertigo) 01/01/1980 - "The only side-effects considered to be related to primidolol were mild postural dizziness of short duration (2 patients), mild nausea (1 patient) and orthostatic vertigo (1 patient). "
3.	Tachycardia (Tachyarrhythmias) 03/01/1981 - "Concurrent propranolol 80 mg or primidolol 100 mg (a cardioselective beta-blocker) increased the severity and duration of the postural hypotensive response, with lowest mean systolic blood pressure (BP) of 79 +/- 7 and 75 +/- 9 mm Hg. There was no effect on the orthostatic release of norepinephrine but there was attenuation of the postural tachycardia. "
4.	Nausea 01/01/1980 - "The only side-effects considered to be related to primidolol were mild postural dizziness of short duration (2 patients), mild nausea (1 patient) and orthostatic vertigo (1 patient). "
5.	Dizziness (Lightheadedness) 01/01/1980 - "The only side-effects considered to be related to primidolol were mild postural dizziness of short duration (2 patients), mild nausea (1 patient) and orthostatic vertigo (1 patient). "

Related Drugs and Biologics

1.	Adrenergic Receptors (Adrenergic Receptor)
2.	Antihypertensive Agents (Antihypertensives)
3.	Propranolol (Inderal)
4.	Norepinephrine (Noradrenaline)