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ICI 89406

RN given refers to parent cpd

Also Known As:

ICI 89 406; ICI 89,406; ICI-89406; urea, N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-N'-phenyl-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Propanolamines: 4
      - ICI 89406: 4
- Alcohols: 595
  - Amino Alcohols: 20
    - Propanolamines: 4
      - ICI 89406: 4
  - Propanols: 3
    - Propanolamines: 4
      - ICI 89406: 4

Related Diseases

1.	Angina Pectoris 07/01/1980 - "These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris. " 07/01/1980 - "Clinical, electrocardiographic, and hemodynamic effects of ICI 89,406, a new cardioselective beta-adrenoceptor antagonist with intrinsic sympathomimetic activity, in patients with angina pectoris." 07/01/1980 - "ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease. "
2.	Glioma (Gliomas) 10/01/1986 - "A series of inhibition curves was generated with the unlabeled ligands ICI 89,406 (beta 1-selective) and ICI 118,551 (beta 2-selective), using membranes prepared from C6 glioma cells. " 07/01/1986 - "The selectivity of [125I]iodopindolol, [125I]iodocyanopindolol, [125I]iodohydroxybenzylpindolol and [3H]dihydroalprenolol for beta-1 and beta-2 adrenergic receptors was assessed by inhibiting the binding of each radioligand with the beta-1-selective unlabeled ligand ICI 89,406 at increasing concentrations of the radioligand, using membranes prepared from C6 glioma cells, which have both beta-1 and beta-2 adrenergic receptors. "
3.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/1983 - "The hemodynamic effects of seven different beta-blockers (propranolol, atenolol, acebutolol, ICI 72,222, ICI 89,406, and pindolol) were studied at rest in patients with ischemic heart disease. "
4.	Coronary Artery Disease (Coronary Atherosclerosis) 07/01/1980 - "ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease. "

Related Drugs and Biologics

1.	Adrenergic Receptors (Adrenergic Receptor)
2.	Ligands
3.	Iodocyanopindolol
4.	beta-2 Adrenergic Receptors
5.	Sympathomimetics (Sympathomimetic Amines)
6.	Propranolol (Inderal)
7.	Pindolol (LB 46)
8.	Dihydroalprenolol
9.	Atenolol (Tenormin)
10.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)