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alpha-neoendorphin

precursor or leucine enkephalin family

Also Known As:

alpha-neo-endorphin; prodynorphin-derived peptide YGGFLRKYPK

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protein Precursors: 37
    - alpha-neoendorphin: 16
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Opioid Peptides: 1339
        Endorphins: 977
        alpha-neoendorphin: 16
- Peptides: 82426
  - Neuropeptides: 6772
    - Opioid Peptides: 1339
      - Endorphins: 977
        alpha-neoendorphin: 16

Experts

1.	Andersson, Malin: 2 articles (02/2012 - 01/2011)
2.	Hanrieder, Jörg: 2 articles (02/2012 - 01/2011)
3.	Ljungdahl, Anna: 2 articles (02/2012 - 01/2011)
4.	Coveñas, Rafael: 1 article (01/2013)
5.	Duque, Ewing: 1 article (01/2013)
6.	Díaz-Cabiale, Zaida: 1 article (01/2013)
7.	Mangas, Arturo: 1 article (01/2013)
8.	Narváez, José Angel: 1 article (01/2013)
9.	Salinas, Pablo: 1 article (01/2013)
10.	Bergquist, Jonas: 1 article (01/2011)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 02/01/1999 - "In this study, we have investigated behavioral responses and alterations in the expression of opioid neuropeptide precursors preproenkephalin-A (PPE-A, encoding methionine- and leucine-enkephalin) and preproenkephalin-B (PPE-B), the precursor encoding dynorphins (dynorphin A1-17 and B1-13, leucine-enkephalin, and alpha-neoendorphin) in striatal output pathways of the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease. "
2.	Alzheimer Disease (Alzheimer's Disease) 02/09/1995 - "Competition studies with dynorphin B and alpha-neoendorphin gave flat inhibition curves with Hill coefficients of 0.31 +/- 0.04 and 0.49 +/- 0.09 in the control brains and 0.38 +/- 0.05 and 0.48 +/- 0.08 in the Alzheimer's disease brains, respectively. " 02/09/1995 - "The pI50 values for dynorphin B and alpha-neoendorphin were 8.73 +/- 0.17 and 8.48 +/- 0.09, respectively, in the control brains and 9.30 +/- 0.22 and 8.70 +/- 0.15 in the Alzheimer's disease brains. "
3.	Dyskinesias (Dyskinesia) 01/01/2011 - "Nigral levels of dynorphin B and alpha-neoendorphin strongly correlated with the severity of dyskinesia. " 02/14/2012 - "In the examples presented here, the peak intensities of dynorphin B, alpha-neoendorphin and substance P were found to be significantly increased in the dorsolateral, but not the dorsomedial, striatum of animals with severe dyskinesia involving facial, trunk and orolingual muscles (Fig. " 02/14/2012 - "Furthermore, MALDI IMS revealed a correlation between dyskinesia severity and levels of des-tyrosine alpha-neoendorphin, representing a previously unknown mechanism of functional inactivation of dynorphins in the striatum as the removal of N-terminal tyrosine reduces the dynorphin's opioid-receptor binding capacity(9). " 01/01/2011 - "The nigral dynorphins associated with L-DOPA-induced dyskinesia were not those with high affinity to kappa opioid receptors, but consisted of shorter peptides, mainly dynorphin B and alpha-neoendorphin that are known to bind and activate mu and delta opioid receptors. "
4.	Seizures (Absence Seizure) 01/01/1990 - "The release of alpha-neoendorphin from rat hippocampus following kainic acid-induced seizures." 01/01/1983 - "The delta-receptor agonist (D-Ala2,D-Leu5-enkephalin, DADL 5-40 micrograms) and alpha-neoendorphin (20-40 micrograms) show pro- and anticonvulsant properties towards clonic and tonic seizures, respectively. "
5.	Neuroblastoma 04/01/1983 - "Neuroblastoma x glioma hybrid cells (NG 108CC15) and tumors derived thereof were examined for dynorphin- and alpha-neoendorphin-like material. " 01/01/1987 - "Five opioid peptides (immunoreactivity) derived from their respective opioid precursors were measured in neuroblastoma-glioma hybrid cells (NG 108CC15; pmol/g protein): heptapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Phe), 13.0 +/- 2.6; alpha-neoendorphin, 6.6 +/- 0.8; dynorphin A, 4.4 +/- 1.5; dynorphin A 1-8, 1.3 +/- 0.29; beta-endorphin, 0.3 +/- 0.13. "

Related Drugs and Biologics

1.	Dynorphins (Dynorphin)
2.	Leucine Enkephalin
3.	rimorphin
4.	Opioid Analgesics (Opioids)
5.	Oxidopamine (6 Hydroxydopamine)
6.	Neuropeptides
7.	Methionine (L-Methionine)
8.	preproenkephalin
9.	Methionine Enkephalin
10.	Opioid Peptides (Opioid Peptide)