clophen A50

03/01/1984 - "A dose-dependent enhancement in number and area of islands by an additional treatment with Clophen A 50 of DEN-pretreated animals (2-100 mg/kg body weight/weekly, for 7 weeks) was observed in both age groups. "
01/01/1996 - "(intraperitoneal) injection with 20, 100 and 500 mg Clophen A50/kg body weight. "
01/01/1996 - "A six-fold, dose-dependent, significant increase in EROD activity was found at exposure day 10 in flounder receiving 100 or 500 mg Clophen A50/kg body weight. "
06/01/1995 - "After a break of one week the rats received 10 mg Clophen A50/kg body weight as promotor for possible isocyanate induced tumorigenic lesions twice a week for eight weeks. "
01/01/1990 - "Male and female Sprague-Dawley rats, 4-6 days old were exposed for 3 weeks (6 h/day, 5 days/week) to 2-nitropropane vapours of 0, 25, 40, 50, 80 and 125 ppm. One week later polychlorinated biphenyls (Clophen A50, 10 mg/kg body weight) were administered for promotion twice a week for 8 weeks. "

07/05/2004 - "Clophen A50, on disease resistance to the aetiological agent of rainbow trout fry syndrome, Flavobacterium psychrophilum, were investigated. "

08/01/1995 - "PB and Clophen A50 induced N-oxidation to 38.9% (4 x) and 27.8% (3 x), and to a lesser extent NNAL formation and alpha-hydroxylation (2 x), Starvation mainly increased N-oxidation with a time-dependent increase from 1 day to 3 days of starvation (4 x and 8 x versus controls), whereas alpha-hydroxylation and NNAL formation was elevated only after 1 day starvation. "
08/01/1995 - "In control male SD and F344 rats, jejunal presystemic metabolism was 2.3-fold higher (56.4% and 60.8% respectively), mainly because of a 4-fold increase in NNAL formation (44.1% and 48.5%)> total NNK metabolism was also induced in female rats by starvation (84.4% metabolites), acetone (89.3%), phenobarbital PB, 75.3%) and Clophen A50 (61%). "

02/01/1987 - "The Clophen A50 treatment (100 mg total, during Days 16-60), which causes fetal death, was correlated to significantly higher levels of estrone sulfate (p less than 0.05) and 11-ketotetranor PGF metabolite (p less than 0.01) during Days 47-60 (Period IV) of gestation."