lactotriaosylceramide

Also Known As:

GlcNAc-1-3-Gal-1-4-Glc-1-Cer; Lc3 ceramide; N-acetylglucosaminyl-1-3-galactosyl-1-4-glucosyl-1-ceramide; Ceramide, 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Zijun: 1 article (07/2012)
2.	Li, Yunsen: 1 article (07/2012)
3.	Liu, Haiyan: 1 article (07/2012)
4.	Liu, Zhenming: 1 article (07/2012)
5.	Ma, Xiao: 1 article (07/2012)
6.	Wang, Yanping: 1 article (07/2012)
7.	Wang, Zheng: 1 article (07/2012)
8.	Wen, Lijun: 1 article (07/2012)
9.	Wu, Depei: 1 article (07/2012)
10.	Yu, Yunhui: 1 article (07/2012)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/01/2012 - "High expression of lactotriaosylceramide, a differentiation-associated glycosphingolipid, in the bone marrow of acute myeloid leukemia patients." 01/07/1983 - "Our analysis indicated both quantitative and qualitative differences between the gangliosides of acute leukemia and those of normal leukocytes: 1, the absolute amount of ganglioside was decreased in the acute leukemia cells; 2, in general, acute leukemias had a more simplified ganglioside pattern in that they contained a greater proportion of the short-chain ganglioside, II3NeuAc-LacCer (GM#); 3, all of the acute leukemia cells contained reduced quantities of the ganglioside N-acetylneuraminosyl-lactotriaosylceramide, a compound previously found only in normal leukocytes; and 4, a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal leukocytes, was isolated from the cells of one patient with acute nonlymphoblastic leukemia. "
2.	Neoplasms (Cancer) 05/15/1994 - "A new method for assaying the activity of the enzyme that catalyzes the formation of a cancer-associated glycolipid, paragloboside (nLc4Cer), from lactotriaosylceramide (Lc3Cer) and UDP-galactose has been developed that is based on a time-resolved fluoroimmunoassay (TRFIA) with a Europium (Eu)-chelate-labeled antibody. " 04/01/1992 - "Galactosyltransferase activities in sera of cancer patients were determined by assaying the formation of paragloboside from UDP-galactose and lactotriaosylceramide immobilized on microtiter plates by means of the enzyme-linked immunosorbent assay using a monoclonal antibody, H-11, directed to paragloboside. "
3.	Leukemia 01/07/1983 - "Our analysis indicated both quantitative and qualitative differences between the gangliosides of acute leukemia and those of normal leukocytes: 1, the absolute amount of ganglioside was decreased in the acute leukemia cells; 2, in general, acute leukemias had a more simplified ganglioside pattern in that they contained a greater proportion of the short-chain ganglioside, II3NeuAc-LacCer (GM#); 3, all of the acute leukemia cells contained reduced quantities of the ganglioside N-acetylneuraminosyl-lactotriaosylceramide, a compound previously found only in normal leukocytes; and 4, a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal leukocytes, was isolated from the cells of one patient with acute nonlymphoblastic leukemia. "
4.	Adenocarcinoma 11/15/1987 - "In striking contrast, significant activity of a beta 1----3N-acetylglucosaminyltransferase responsible for synthesis of lactotriaosylceramide (Lc3) was found in various cases of colonic adenocarcinoma and cell lines, but was undetectable in normal colonic epithelial cells. "

Related Drugs and Biologics

1.	Uridine Diphosphate Galactose (UDP Galactose)
2.	Enzymes
3.	paragloboside (neolactotetraosylceramide)
4.	Immunosorbents
5.	Glycosphingolipids
6.	Glycolipids
7.	Gangliosides
8.	Galactosyltransferases
9.	Europium
10.	Monoclonal Antibodies