|1.||Gleason-Guzman, Mary: 2 articles (11/2008 - 11/2005)|
|2.||Hurley, Laurence H: 2 articles (11/2008 - 11/2005)|
|3.||Gokhale, Vijay: 1 article (11/2008)|
|4.||Carey, Steven S: 1 article (11/2008)|
|5.||Fellows, Ingrid M: 1 article (11/2005)|
|6.||Dexheimer, Thomas S: 1 article (11/2005)|
|7.||Vankayalapati, Hariprasad: 1 article (11/2005)|
|8.||Whitten, Jeffrey P: 1 article (11/2005)|
|9.||Schwaebe, Michael: 1 article (11/2005)|
|10.||Sousa, M E: 1 article (01/2005)|
11/01/2008 - "By understanding the mechanism of psorospermin-induced MDR modulation, psorospermin and similar compounds can be combined with other chemotherapies to treat resistant cancers."
11/01/2005 - "In addition, (2'R,3'R) psorospermin in combination with gemcitabine was found to show an at least additive effect in slowing tumor growth of MiaPaCa."
11/01/2005 - "Finally, (2'R,3'R) psorospermin was found to be as effective as gemcitabine in slowing tumor growth in vivo in a MiaPaCa pancreatic cancer model. "
11/01/2005 - "It has also been shown to alkylate DNA through an epoxide-mediated electrophilic attack, and this alkylation is greatly enhanced at specific sites by topoisomerase II. In this article, we describe the synthesis of the two diastereomers of O5-methyl psorospermin and their in vitro activity against a range of solid and hematopoietic tumors. "
01/01/2005 - "Examples of the "hit" compounds involved in cancer therapy, namely DMXAA, psorospermin, mangiferin, norathyriol, mangostins, and AH6809, a prostanoid receptor antagonist, are also mentioned. "
|3.||AIDS-Related Lymphoma (Lymphoma, AIDS Related)
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
11/01/2008 - "Flow cytometry shows that doxorubicin-resistant multiple myeloma cells (8226/D40) pretreated with psorospermin enhance intracellular retention of doxorubicin compared with control (75% versus 38%). "
11/01/2008 - "Psorospermin, a natural product, is a topoisomerase II-directed DNA alkylating agent active against multidrug-resistant (MDR) cell lines, including multiple myeloma. "
|1.||Type II DNA Topoisomerases (Topoisomerase II)
|2.||DNA (Deoxyribonucleic Acid)
|1.||Drug Therapy (Chemotherapy)