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diacetolol
RN given refers to parent cpd without isomeric designation
Also Known As:
M&B 16,942; RS-1-(4-acetamido-2-acetylphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride; acetyl acebutolol; diacetolol monohydrochloride; diacetolol, (+)-isomer; diacetolol, (+-)-isomer; diacetolol, monohydrochloride, (+-)-isomer; acetamide, N-(3-acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, (+-)-
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
Phenoxypropanolamines: 1
Acebutolol: 363
diacetolol: 4
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
Phenoxypropanolamines: 1
Acebutolol: 363
diacetolol: 4
Propanols: 3
Propanolamines: 4
Phenoxypropanolamines: 1
Acebutolol: 363
diacetolol: 4
Experts
1.
Burm, Jin Pil
: 1 article (08/2002)
2.
Choi, Jun Shik
: 1 article (08/2002)
Related Diseases
1.
Liver Diseases (Liver Disease)
04/01/1985 - "
Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.
"
04/01/1985 - "
The pharmacokinetics of acebutolol and its major metabolite, diacetolol, following a single 400 mg oral dose, were investigated in patients with liver disease.
"
2.
Liver Failure
08/01/2002 - "
The ratio of the diacetolol to total acebutolol in plasma (i.e., metabolite percentage rate) was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits.
"
08/01/2002 - "
Pharmacokinetic characteristics of acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure.
"
08/01/2002 - "
Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.
"
3.
Hypertension (High Blood Pressure)
05/01/1985 - "
The existence of a long-lived active metabolite (diacetolol) confers a 24-hour duration of action, which permits effective use of a once-daily regimen, particularly for hypertension.
"
4.
Essential Hypertension
04/01/1982 - "
Antihypertensive effect of diacetolol in essential hypertension.
"
Related Drugs and Biologics
1.
Acebutolol (Prent)
2.
Carbon Tetrachloride (Tetrachloromethane)
3.
Antihypertensive Agents (Antihypertensives)
Related Therapies and Procedures
1.
Oral Administration