macbecin II

from Norcardia sp. No. C-14919; belongs to ansamycin group of antibiotics; structure in second source

Also Known As:

((4Z,6Z,10Z)-20,22-dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo(16.3.1)docosa-4,6,10,19,21,23-hexaen-9-yl) carbamate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Colonic Neoplasms (Colon Cancer) 04/01/2010 - "Our results demonstrate that Macbecin II is specifically active in colon cancer cells having a SMAD4-negative background and thus is a potential candidate for further investigation in a drug discovery perspective." 04/01/2010 - "Chemogenomic analysis identifies Macbecin II as a compound specific for SMAD4-negative colon cancer cells."
2.	Tuberous Sclerosis 2 11/16/2004 - "We performed a small synthetic lethal screen and identified a compound (macbecin II) that has reduced activity in cells with RNA interference-mediated decrease in the expression of tuberous sclerosis 2. Thus, we have developed a microarray-based screening system for testing the effects of small molecules on mammalian cells by using an imaging-based readout. "