codorphone

analgesic activity in range of morphine & pentazocine but with no physical dependence caused in rats; RN given refers to parent cpd

Also Known As:

TR 5109; TR-5109; TR5109; codorphone hydrochloride; conorphone; Morphinan-6-one, 17-cyclopropylmethyl-4,5-epoxy-8-ethyl-3-methoxy-, hydrochloride, (5 alpha,8 beta)-

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Postoperative Pain 03/01/1984 - "These data suggest that while 40 mg of conorphone may not be well tolerated clinically, 20 mg of conorphone may be an alternative to 60 mg of codeine for postoperative pain." 03/01/1984 - "The analgesic efficacy of two doses of conorphone (20 and 40 mg), a mixed agonist-antagonist analgesic, were compared to two doses of codeine for postoperative pain in the oral surgery model. "
2.	Vomiting 03/01/1984 - "The 40 mg dose of conorphone resulted in a high incidence of side effects (25/30 subjects) such as drowsiness, dizziness, nausea and vomiting. "
3.	Pain (Aches) 03/01/1984 - "Comparison of conorphone, a mixed agonist-antagonist analgesic, to codeine for postoperative dental pain."
4.	Nausea 03/01/1984 - "The 40 mg dose of conorphone resulted in a high incidence of side effects (25/30 subjects) such as drowsiness, dizziness, nausea and vomiting. "
5.	Myocardial Infarction 11/01/1988 - "[Effect of conorphone on the dimensions of the myocardial infarct and the ultrastructural changes in the adjacent tissue]."

Related Drugs and Biologics

1.	Codeine (Codeine Phosphate)
2.	Analgesics (Analgesic Drugs)

Related Therapies and Procedures

1.	Oral Surgery (Maxillofacial Surgery)