rebaudioside A

glucoside isolated from the leaves of the paraguayan shrub, Stevia rebaudiana; has taste properties superior to stevioside; structure in first source

Also Known As:

19-O-beta-glucopyranosyl-13-O-(beta-glucopyranosyl(1-2)-beta-glucopyranosyl(1-3))-beta-glucopyranosyl-13-hydroxykaur-16-en-19-oic acid; 19-O-beta-glucopyranosyl-13-O-(beta-glucopyranosyl(1-2)-beta-glucopyranosyl(1-3))-beta-glucopyranosylsteviol

Networked: 24 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Kaurane Diterpenes: 93
        rebaudioside A: 24

Experts

1.	Hermansen, Kjeld: 2 articles (01/2005 - 10/2004)
2.	Ajat, Mokrish: 1 article (10/2021)
3.	Hamzah, Hazilawati: 1 article (10/2021)
4.	Idris, Mohd Faiz: 1 article (10/2021)
5.	Ilias, Amirul Nazhan: 1 article (10/2021)
6.	Ismail, Intan Safinar: 1 article (10/2021)
7.	Mohd Mohidin, Taznim Begam: 1 article (10/2021)
8.	Chen, Zekun: 1 article (01/2021)
9.	Di, Guohu: 1 article (01/2021)
10.	Fan, Junting: 1 article (01/2021)

Related Diseases

1.	Obesity 01/01/2021 - "We evaluated the synergistic antiangiogenesis, antiadipogenic and antilipogenic efficacy of standardized rebaudioside A, sativoside, and theasaponin E1 formulations (RASE1) in vitro in human umbilical vein endothelial cells (HUVECs), 3T3-L1 preadipocytes respectively, and in vivo using a high-fat and carbohydrate diet-induced obesity mouse model. " 01/01/2017 - "The purpose of the present study was to examine the effects of the artificial sweetener, rebaudioside A (Reb-A), on circadian rhythms, in vivo insulin action, and the susceptibility to diet-induced obesity. " 05/31/2019 - "Long-term low-dose Rebaudioside A consumption had little effect on glucose metabolism and weight gain; however, its impact on gut microbial taxa should be further examined in populations exhibiting dysbiosis such as obesity." 01/01/2020 - "Our study aimed to determine the impact of newer NCS including Rebaudioside A and sucralose on NASH using high fat diet induced obesity mouse model by substituting fructose and sucrose with NCS in the drinking water. " 03/01/2015 - "We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the hepatic effects of lipotoxicity using a mouse model of obesity and insulin resistance. "
2.	Insulin Resistance 01/01/2020 - "Additionally, Rebaudioside A improved endoplasmic reticulum (ER) stress related gene expressions, fasting glucose levels, insulin sensitivity and restored pancreatic islet cell mass, neuronal innervation and microbiome composition. " 03/01/2015 - "We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the hepatic effects of lipotoxicity using a mouse model of obesity and insulin resistance. "
3.	Fibrosis (Cirrhosis) 01/01/2020 - "However, in comparison to fructose and sucrose, Rebaudioside A significantly improved liver enzymes, hepatic steatosis and hepatic fibrosis. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system."
5.	Type 2 Diabetes Mellitus (MODY) 11/01/2022 - "We aimed to characterize the pharmacokinetic and pharmacodynamic properties of rebaudioside A and its metabolites in patients with early-onset type 2 diabetes mellitus (T2DM). " 11/01/2022 - "Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial." 07/01/2008 - "These results suggest that chronic use of 1000mg rebaudioside A does not alter glucose homeostasis or blood pressure in individuals with type 2 diabetes mellitus." 07/01/2008 - "Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus." 01/01/2005 - "The aim of this study was to elucidate if long-term administration of rebaudioside A, another glycoside isolated from the plant SrB, could improve glycemic control and lower blood pressure in an animal model of type 2 diabetes. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Fructose
3.	Sucrose (Saccharose)
4.	Enzymes
5.	Carbohydrates
6.	theasaponin E1
7.	hesperetin
8.	stevioside
9.	Sweetening Agents (Sweeteners)
10.	Glycosides

Related Therapies and Procedures

1.	Glycemic Control
2.	Therapeutics