|1.||Eling, Thomas E: 7 articles (05/2014 - 07/2003)|
|2.||Piazza, Gary A: 7 articles (09/2013 - 10/2003)|
|3.||Keeton, Adam B: 5 articles (09/2013 - 12/2009)|
|4.||Gary, Bernard D: 5 articles (09/2013 - 12/2009)|
|5.||Moon, Yuseok: 5 articles (04/2010 - 05/2005)|
|6.||Baek, Seung Joon: 4 articles (05/2014 - 03/2005)|
|7.||Tinsley, Heather N: 4 articles (09/2013 - 12/2009)|
|8.||Bottone, Frank G: 4 articles (11/2005 - 07/2003)|
|9.||Li, Nan: 3 articles (09/2013 - 10/2010)|
|10.||Li, Yonghe: 3 articles (09/2013 - 10/2010)|
01/01/2012 - "Sulindac sulfide, a non-steroidal anti-inflammatory drug (NSAID), stimulates apoptosis of tumor cells and is thus effective against malignancy. "
02/01/2005 - "In this study, we aimed to investigate whether sulindac sulfide can induce apoptosis in sinonasal cancer cells and what type of molecular mechanisms induces the death of sinonasal cancer cells. "
05/01/2013 - "SSA potently inhibited the growth of lung tumor cells with IC50 values of 2 to 5 μmol/L compared with 44 to 52 μmol/L for sulindac sulfide. "
05/01/2013 - "Nonsteroidal anti-inflammatory drugs such as sulindac sulfide have shown promising antineoplastic activity in multiple tumor types, but toxicities resulting from COX inhibition limit their use in cancer therapy. "
11/29/2012 - "Here, we show that the NSAID, sulindac sulfide (SS) can potently inhibit the invasion of human MDA-MB-231 breast and HCT116 colon tumor cells in vitro at concentrations less than those required to inhibit tumor cell growth. "
07/01/2001 - "In the present study we compared the effects of sulindac sulfide to those of 12-0-tetradecanoylphorbol ester (TPA) on the human promyelocytic leukemia cell line HL60. "
07/01/2001 - "Therefore, sulindac sulfide and related compounds may be useful in the treatment of leukemia and other neoplasms, especially when used together with agents that increase cellular levels of p21Cip1 or p27KiP1."
|3.||Colonic Neoplasms (Colon Cancer)
06/01/2012 - "In this study, we investigated the possibility that colon cancer cells are sensitized to sulindac sulfide-induced apoptosis by docosahexaenoic acid (DHA), via activation of the DR/extrinsic apoptotic pathway. "
06/01/2012 - " Our findings collectively support the utility of a combination of sulindac sulfide and DHA in the effective prevention and treatment of colon cancer."
06/01/2012 - "Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis."
01/01/2012 - "Here, we show that inhibition of autophagy under serum-deprived conditions resulted in significant reductions of sulindac sulfide-induced apoptosis in HT-29 colon cancer cells. "
01/01/2012 - "The NSAID sulindac sulfide induces apoptosis in colon cancer cells. "
|4.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2014 - "Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells."
04/01/2005 - "Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells."
04/01/2005 - "The present study shows that despite the ability of sulindac sulfide to behave as a protonophoric uncoupler, CsA-sensitive opening of mitochondrial permeability transition pore contributes little to its pro-apoptotic effect in colorectal cancer cells."
04/01/2005 - "To assess the possible contribution of uncoupling to their antineoplastic properties, we compared the effect of sulindac sulfide (SS), an acidic NSAID and NS-398, a non-acidic tricyclic, on mitochondrial function and apoptosis in colorectal cancer cell lines (HT29, Caco-2, HCT15 and HCT116). "
07/11/2003 - "At micromolar concentrations, sulindac sulfide stimulated apoptosis and inhibited the growth of colorectal cancer cells on soft agar. "
01/01/2005 - "Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells."
03/01/2000 - "Therefore, we asked whether the NSAID, sulindac sulfide, and the phenolic antioxidant, caffeic acid phenethyl ester (CAPE), affected FAK expression or tyrosine phosphorylation in human colon carcinoma cells. "
06/01/1999 - "Both sulindac sulfide and sulfone inhibited colon carcinoma cell growth and prostaglandin production in vitro, but sulindac sulfone had no effect on the growth of colon cancer cell xenografts in nude mice."
01/01/2001 - "We have used colonic carcinoma and adenoma cell lines to study the effects of the NSAID sulindac sulfide, its COX-inactive metabolite, sulindac sulfone, and the isoenzyme-specific inhibitors SC58125, SC236 and SC58560 on tumor cell growth in relation to COX-2 expression and prostaglandin production. "
03/01/2011 - "Amongst 6 NSAIDs tested: sulindac, sulindac sulfide, sulindac sulfone, acetylsalicylic acid, nimesulide, and rofecoxib, viability of ovarian carcinoma cells was compromised most strongly by sulindac and sulindac sulfide and concerned all the cell lines tested: SKOV-3, MDAH 2774, OVCA-1, and OVP-10. "
|1.||sulindac sulfone (exisulind)
|3.||Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
|4.||Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
|6.||Messenger RNA (mRNA)
|7.||dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)
|9.||NF-kappa B (NF-kB)
|1.||Heterologous Transplantation (Xenotransplantation)