4-toluenesulfonamide

RN given refers to parent cpd

Also Known As:

4-methylbenzenesulfonamide; 4-toluenesulfonamide hydrochloride; 4-toluenesulfonamide, 6-(14)C-labeled; 4-toluenesulfonamide, mercury (+2) salt (1:1); 4-toluenesulfonamide, mercury (+2) salt (2:1); 4-toluenesulfonamide, monopotassium salt; 4-toluenesulfonamide, monosilver salt; 4-toluenesulfonamide, monosodium salt; 4-toluenesulfonylamide; para-toluenesulfonamide; para-toluenesulphonamide; Benzenesulfonamide, 4-methyl-

Networked: 11 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Zhong, Nan-Shan: 4 articles (10/2021 - 01/2016)
2.	Zhong, Nanshan: 3 articles (11/2015 - 10/2009)
3.	Guh, Jih-Hwa: 2 articles (10/2021 - 01/2018)
4.	Hsu, Jui-Ling: 2 articles (10/2021 - 01/2018)
5.	Leu, Wohn-Jenn: 2 articles (10/2021 - 01/2018)
6.	Guan, Wei-Jie: 2 articles (04/2018 - 01/2016)
7.	Li, Shi-Yue: 2 articles (04/2018 - 01/2016)
8.	Wu, Yizhuang: 2 articles (08/2013 - 10/2009)
9.	Hsu, Lih-Ching: 1 article (01/2018)
10.	Liu, Shih-Ping: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2015 - "Para-toluenesulfonamide (PTS) has been implicated with anticancer effects against a variety of tumors. " 11/01/2023 - "This study aimed to investigate the involvement of CA9 in the anti-tumor activity of para-toluenesulfonamide (PTS) and elucidate its mechanism of action against breast cancer both in vitro and in vivo. " 08/01/2013 - "Para-toluenesulfonamide (PTS), a unique antitumor drug for local intratumoral injection, shows an efficacy of severely suppressing solid tumor growth with mild side effects in clinical trials. " 12/14/2012 - "As a unique antitumor agent in form of lipophilic fluid for local injection, para-toluenesulfonamide (PTS) produces mild side effects while necrotizing the tumor tissues quickly and efficiently. " 01/01/2018 - "Para-Toluenesulfonamide Induces Anti-tumor Activity Through Akt-Dependent and -Independent mTOR/p70S6K Pathway: Roles of Lipid Raft and Cholesterol Contents."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2016 - "Effects of para-toluenesulfonamide intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: A multi-center, non-randomized, single-arm, open-label trial." 10/01/2009 - "Gemcitabine plus cisplatin chemotherapy with concurrent para-toluenesulfonamide local injection therapy for peripherally advanced nonsmall cell lung cancer larger than 3 cm in the greatest dimension."
3.	Airway Obstruction (Choking) 01/01/2016 - "Effects of para-toluenesulfonamide intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: A multi-center, non-randomized, single-arm, open-label trial." 04/01/2018 - "Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study."
4.	Breast Neoplasms (Breast Cancer) 11/01/2023 - "This study aimed to investigate the involvement of CA9 in the anti-tumor activity of para-toluenesulfonamide (PTS) and elucidate its mechanism of action against breast cancer both in vitro and in vivo. " 11/01/2023 - "Para-toluenesulfonamide, a novel potent carbonic anhydrase inhibitor, improves hypoxia-induced metastatic breast cancer cell viability and prevents resistance to αPD-1 therapy in triple-negative breast cancer."
5.	Hepatocellular Carcinoma (Hepatoma) 02/01/2008 - "To investigate the dose-effect relationship of para-toluenesulfonamide (PTS) for treatment of hepatocellular carcinoma in rats. " 02/01/2008 - "[Dose-effect relationship of para-toluenesulfonamide for treatment of hepatocellular carcinoma in rats]." 12/14/2012 - "Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma."

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	Phosphotransferases (Kinase)
3.	Lipids
4.	TOR Serine-Threonine Kinases
5.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
6.	Cisplatin (Platino)
7.	Cholesterol
8.	Carbonic Anhydrase Inhibitors
9.	Gemcitabine

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Drug Therapy (Chemotherapy)
4.	Castration